Aging is the most significant risk factor for neurodegenerative disorders that are typified by cognitive deficits. Our recent work utilizing BubR1 hypomorphic (BubR1H/H) mice, an accelerated aging model, has revealed that genetic inhibition of the endogenous Wnt pathway inhibitor secreted frizzled related protein 3 (sFRP3) plays a neuroprotective role. Neuroinflammation has been suggested as a pathological hallmark of age-related neurodegeneration mediating cognitive impairment. However, whether sFRP3 inhibition has a neuroprotective effect on neuroinflammatory gliosis in BubR1H/H mice is unknown.

中文翻译：

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sFRP3的遗传抑制阻止了加速衰老的小鼠模型中的神经胶质反应性。

衰老是以认知缺陷为代表的神经退行性疾病最重要的危险因素。我们最近利用BubR1亚型（BubR1H / H）小鼠（一种加速衰老模型）的工作表明，内源性Wnt途径抑制剂分泌的卷曲相关蛋白3（sFRP3）的遗传抑制起神经保护作用。神经炎症已被认为是介导认知障碍的年龄相关性神经变性的病理标志。但是，尚不知道sFRP3抑制是否对BubR1H / H小鼠的神经炎性神经胶质增生具有神经保护作用。