Lambda-cyhalotherin (LCT) is a pyrithroid type 2 pesticide that is broadly utilized in pest control in public health, animal health, and agriculture. Although claiming that LCT has a low mammalian toxicity, several investigations reported its mammalian hepatotoxicity by mediating oxidative stress causes severe hepatotoxicity and liver damage. LCT significantly decreased catalase (CAT), superoxide dismutase (SOD), and total thiol (T. thiol) and increased lipid peroxidation (LPO). mRNA and protein expression levels of p53 were upregulated, whereas Bcl-2 mRNA and protein expression levels were downregulated in LCT-intoxicated animals. Also, light microscopic and ultrastructure studies for liver tissues of LCT-intoxicated animals showed mononuclear leukocytic infiltration in the parenchyma, congested portal vein with thickened wall, and proliferation of bile duct and hepatocytes with cytoplasmic vacuolations, fatty changes, and collagen fibers. Panax ginseng co-treatment attenuated oxidative stress biomarkers. Both tested doses of Panax ginseng (100 and 200 mg /kg b. wt./day) significantly decreased p53 and elevate Bcl-2 mRNA and protein expression levels and reveals significant amelioration and restoration of normal histology and ultrastructure of liver, but 200 mg/kg b. wt. of Panax ginseng seems to be more potent. Panax ginseng exhibited ameliorative effect against hepatic oxidative stress, apoptosis, histopathological, and ultrastructural changes induced by LCT.

中文翻译：

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人参在改善三氯氟氰菊酯所致肝损伤中可能作用的组织学、超微结构和生化研究

Lambda-cyhalotherin (LCT) 是一种 2 型拟除虫菊酯杀虫剂，广泛用于公共卫生、动物健康和农业中的害虫防治。尽管声称 LCT 对哺乳动物的毒性较低，但一些研究报告称其通过介导氧化应激对哺乳动物的肝毒性导致严重的肝毒性和肝损伤。LCT 显着降低过氧化氢酶 (CAT)、超氧化物歧化酶 (SOD) 和总硫醇 (T. thiol) 并增加脂质过氧化 (LPO)。在 LCT 中毒动物中，p53 的 mRNA 和蛋白质表达水平上调，而 Bcl-2 mRNA 和蛋白质表达水平下调。此外，对 LCT 中毒动物肝脏组织的光学显微镜和超微结构研究显示，实质内有单核白细胞浸润，门静脉充血，壁增厚，胆管和肝细胞的增殖和细胞质空泡化、脂肪变化和胶原纤维。人参联合治疗减弱了氧化应激生物标志物。两种测试剂量的人参（100 和 200 毫克/公斤体重/天）显着降低 p53 并提高 Bcl-2 mRNA 和蛋白质表达水平，并显示肝脏正常组织学和超微结构的显着改善和恢复，但 200 /公斤 B. 重量 Panax ginseng 似乎更有效。人参对 LCT 诱导的肝脏氧化应激、细胞凋亡、组织病理学和超微结构变化具有改善作用。两种测试剂量的人参（100 和 200 毫克/千克体重/天）显着降低 p53 并提高 Bcl-2 mRNA 和蛋白质表达水平，并显示肝脏正常组织学和超微结构的显着改善和恢复，但 200 毫克/公斤 B. 重量 Panax ginseng 似乎更有效。人参对 LCT 诱导的肝脏氧化应激、细胞凋亡、组织病理学和超微结构变化具有改善作用。两种测试剂量的人参（100 和 200 毫克/千克体重/天）显着降低 p53 并提高 Bcl-2 mRNA 和蛋白质表达水平，并显示肝脏正常组织学和超微结构的显着改善和恢复，但 200 毫克/公斤 B. 重量 Panax ginseng 似乎更有效。人参对 LCT 诱导的肝脏氧化应激、细胞凋亡、组织病理学和超微结构变化具有改善作用。