Cerebral palsy (CP) is a movement and posture disorder often accompanied by cognitive difficulties which can be assessed using event-related potentials (ERPs), an often-overlooked tool in this population. Here we describe our assessment protocol, examine its feasibility, and validate the use of single-subject ERP analyses in adolescents and young adults with CP, an analysis approach which recognizes the heterogeneity of the clinical population. This study involved a final sample of 9 adolescents/young adults with CP participating in the "MyStory" study (age range 16-29 years, Mage = 25.0 years; 6 female; Gross Motor Function Classification System level I [n = 4], II [n = 2], III [n = 1], IV [n = 1], and V [n = 1]). ERP components were elicited over medial prefrontal and central cortex (error- and correct-related negativities [ERN/CRN], error-positivity [Pe], N100, P200, N200, P300), as well as those generated over occipital cortex (P100, N170). Group and single-subject ERP statistics were computed for ERPs recorded over both areas. Using recently developed data analysis methods (independent components analysis and robust bootstrapped single-subject statistics), we measured the number of participants demonstrating significant condition differences at the timing of each ERP component of interest. We demonstrate good validity for ERPs recorded during 2 of our 3 tasks eliciting frontal activation (eg, 4 of 6 participants with usable data showed a significant single-subject medial frontal negativity condition difference in a context-switching task) and good validity for ERPs derived from a task engaging occipital regions (eg, 8 of 9 participants each showed a significant N170 face-object condition effect).

中文翻译：

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脑瘫年轻人的认知事件相关电位：概念验证研究


脑瘫 (CP) 是一种运动和姿势障碍，通常伴有认知困难，可以使用事件相关电位 (ERP) 进行评估，ERP 是该人群中经常被忽视的工具。在这里，我们描述我们的评估方案，检验其可行性，并验证单受试者 ERP 分析在患有 CP 的青少年和年轻人中的使用，这是一种认识到临床人群异质性的分析方法。这项研究涉及参与“MyStory”研究的 9 名 CP 青少年/年轻人的最终样本（年龄范围 16-29 岁，Mage = 25.0 岁；6 名女性；粗大运动功能分类系统 I 级 [n = 4]， II [n = 2]、III [n = 1]、IV [n = 1] 和 V [n = 1]）。 ERP 成分是在内侧前额叶和中央皮层（错误和正确相关的负性 [ERN/CRN]、错误阳性 [Pe]、N100、P200、N200、P300）以及枕叶皮层生成的 ERP 成分（P100）引发的。 ，N170）。计算两个区域记录的 ERP 的组和单受试者 ERP 统计数据。使用最近开发的数据分析方法（独立成分分析和稳健的引导单受试者统计），我们测量了在每个感兴趣的 ERP 成分的时间点表现出显着状况差异的参与者数量。我们证明了在引发额叶激活的 3 项任务中的 2 项中记录的 ERP 具有良好的有效性（例如，具有可用数据的 6 名参与者中的 4 名在上下文切换任务中显示出显着的单受试者内侧额叶消极条件差异），并且对于导出的 ERP 具有良好的有效性来自涉及枕骨区域的任务（例如，9 名参与者中的 8 名均表现出显着的 N170 面部-物体条件效应）。