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Dextran-Based Nanoparticles to Formulate pH-Responsive Pickering Emulsions: A Fully Degradable Vector at a Day Scale
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-12-03 , DOI: 10.1021/acs.biomac.0c01489 Valentin Maingret 1, 2 , Clémence Courrégelongue 1, 2 , Véronique Schmitt 1 , Valérie Héroguez 2
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-12-03 , DOI: 10.1021/acs.biomac.0c01489 Valentin Maingret 1, 2 , Clémence Courrégelongue 1, 2 , Véronique Schmitt 1 , Valérie Héroguez 2
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Biosourced Pickering emulsion stabilizers with stimuli responsiveness are mostly designed for recycling and do not offer fast degradability as required for drug-delivery applications. Herein, dextran—a hydrophilic and biofriendly polysaccharide obtainable from biomass recovery—was used for the first time as a brick material for the formulation of (bio)degradable pH-sensitive Pickering emulsions. It was first modified with hydrophobic acetal moieties to provide pH-sensitive acetalated dextran. Under acidic conditions, it degrades into three biocompatible (macro)molecules: dextran, ethanol, and acetone. Nanoparticles of acetalated dextran were obtained using the nanoprecipitation process and could be similarly fully hydrolyzed under acidic conditions within 6 h. Then, O/W Pickering emulsions of dodecane (model oil) and medium-chain triglyceride (biocompatible oil) were successfully stabilized using these nanoparticles. pH-induced destabilization of these Pickering emulsions (including nanoparticles degradation) took less than 24 h. Finally, neither accumulation of nanoparticles nor harmful component release happened during the process, making this stimuli-responsive vector safe and environmentally friendly.
中文翻译：
基于右旋糖酐的纳米粒子配制pH敏感的Pickering乳剂：一天可完全降解的载体
具有刺激响应能力的生物来源的Pickering乳化稳定剂主要是为回收设计的，不能提供药物输送应用所需的快速降解性。本文中，右旋糖酐（一种可从生物质回收中获得的亲水性和生物友好性多糖）首次被用作砖砌材料，用于配制（生物）可降解的pH敏感的Pickering乳液。首先用疏水性缩醛部分进行修饰，以提供对pH敏感的缩醛葡聚糖。在酸性条件下，它会降解为三种生物相容性（大分子）分子：葡聚糖，乙醇和丙酮。缩醛葡聚糖的纳米颗粒是使用纳米沉淀法获得的，可以在酸性条件下在6小时内完全水解。然后，使用这些纳米粒子成功地稳定了十二烷（模型油）和中链甘油三酸酯（生物相容性油）的O / W Pickering乳液。pH引起的这些Pickering乳液的不稳定（包括纳米颗粒降解）花费了不到24小时。最终，在此过程中既没有纳米颗粒的积累也没有有害成分的释放，这使得这种刺激响应载体安全环保。
更新日期：2020-12-14
中文翻译：
基于右旋糖酐的纳米粒子配制pH敏感的Pickering乳剂：一天可完全降解的载体
具有刺激响应能力的生物来源的Pickering乳化稳定剂主要是为回收设计的，不能提供药物输送应用所需的快速降解性。本文中，右旋糖酐（一种可从生物质回收中获得的亲水性和生物友好性多糖）首次被用作砖砌材料，用于配制（生物）可降解的pH敏感的Pickering乳液。首先用疏水性缩醛部分进行修饰，以提供对pH敏感的缩醛葡聚糖。在酸性条件下，它会降解为三种生物相容性（大分子）分子：葡聚糖，乙醇和丙酮。缩醛葡聚糖的纳米颗粒是使用纳米沉淀法获得的，可以在酸性条件下在6小时内完全水解。然后，使用这些纳米粒子成功地稳定了十二烷（模型油）和中链甘油三酸酯（生物相容性油）的O / W Pickering乳液。pH引起的这些Pickering乳液的不稳定（包括纳米颗粒降解）花费了不到24小时。最终，在此过程中既没有纳米颗粒的积累也没有有害成分的释放，这使得这种刺激响应载体安全环保。
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