Abstract Attention deficit hyperactivity disorder (ADHD) is a common neuro-developmental disorder. The symptoms of ADHD include difficulty in attention, memory and impulse control. Many pharmaceutical formulations (stimulants and non-stimulants) are available on the market to treat ADHD symptoms. The most commonly used drugs for treatment are amphetamine, methylphenidate, atomoxetine, bupropion, guanfacine and clonidine. In the field of pharmaceuticals, bioanalysis is an important tool used for the quantification of drugs and their metabolites present in biological samples using various analytical methods. Although a number of analytical methods were reported for the quantification of these drugs in biological samples of experimental animals, due to species differences, it is important to develop analytical methods to quantify these drugs in human biological samples to aid forensic and pharmacokinetic studies. In this review, we compile the bio-analytical methods such as spectrophotometry, spectrofluorimetry, mass spectrometry, electrophoresis, liquid chromatography and gas chromatography used for the quantification of ADHD drugs in human biological samples such as blood, plasma, serum, oral fluids, sweat, hair and urine based on earlier published articles from various journals.

中文翻译：

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人体生物样品中 ADHD 药物定量分析方法综述

摘要 注意缺陷多动障碍（ADHD）是一种常见的神经发育障碍。ADHD 的症状包括注意力、记忆力和冲动控制困难。市场上有许多药物制剂（兴奋剂和非兴奋剂）可用于治疗多动症症状。最常用的治疗药物是苯丙胺、哌甲酯、托莫西汀、安非他酮、胍法辛和可乐定。在制药领域，生物分析是使用各种分析方法对生物样品中存在的药物及其代谢物进行定量的重要工具。尽管报道了多种分析方法用于在实验动物的生物样品中对这些药物进行定量，但由于物种差异，重要的是开发分析方法来量化人类生物样品中的这些药物，以帮助法医和药代动力学研究。在这篇综述中，我们汇编了分光光度法、荧光分光光度法、质谱法、电泳法、液相色谱法和气相色谱法等生物分析方法，用于定量人体生物样品（如血液、血浆、血清、口腔液、汗液）中的 ADHD 药物。 ，头发和尿液基于早期发表的各种期刊的文章。