Multifunctional Dual Ionic-Covalent Membranes for Wound Healing,ACS Biomaterials Science & Engineering

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Multifunctional Dual Ionic-Covalent Membranes for Wound Healing
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-12-03 , DOI: 10.1021/acsbiomaterials.0c01512
Zhi Li _{1,

2} , Sihao Chen _{1,

2} , Baiqing Wu _{1,

3} , Zulan Liu _{1,

2} , Lan Cheng _{1,

2,

3} , Yu Bao _{1,

3} , Yan Ma _{2,

3} , Lei Chen ₂ , Xiaoling Tong _{1,

3} , Fangyin Dai _{1,

2,

3}

Affiliation

Wound healing generally has four stages: hemostasis, inflammation, proliferation, and remolding. Most wound dressings only just take one or two phases into account. Herein, to develop a novel wound dressing that works at different stages, the blended alginate sodium/carboxymethyl chitosan membranes with a hydrogel-like structure are fabricated through a freeze-drying process together with a dual-ion (Sr²⁺ and Zn²⁺) cross-linking approach. The fabricated membranes show excellent properties in the swelling ratio, water vapor transmission rate, tensile strength, sustained release, cell adhesiveness, and biocompatibility, proving its general performance for application in wound healing. In particular, the membranes with optimal ion concentrations of 45 mM Sr²⁺ and 0.74 mM Zn²⁺ presented the antibacterial activity and accelerating function of wound healing. More specifically, the formation of epithelium and blood vessels is evidently advanced compared with a commercial dressing in vivo experiment, and the expression of main growth factors such as epidermal growth factor, basic fibroblast growth factor, vascular endothelial growth factor, and transforming growth factor is upregulated which also have good effects on the remolding of skin. The prepared wound dressings in this study have good effects on each stage of wound healing, which is important for the healing of chronic wounds. It provides more choices for wound healing, especially for chronic wound healing.

中文翻译：

用于伤口愈合的多功能双离子共价膜

伤口愈合一般有四个阶段：止血、炎症、增殖和重塑。大多数伤口敷料只考虑一两个阶段。在此，为了开发一种在不同阶段起作用的新型伤口敷料，具有水凝胶状结构的混合海藻酸钠/羧甲基壳聚糖膜通过冷冻干燥工艺与双离子（Sr ²⁺和 Zn ²⁺ ) 交联方法。制备的膜在溶胀率、水蒸气透过率、拉伸强度、缓释、细胞粘附性和生物相容性方面表现出优异的性能，证明了其在伤口愈合中的应用性能。特别是具有 45 mM Sr ^{2+的最佳离子浓度的膜}和0.74 mM Zn ²⁺表现出抗菌活性和促进伤口愈合的作用。更具体地说，与市售敷料的体内实验相比，上皮和血管的形成明显提前，表皮生长因子、碱性成纤维细胞生长因子、血管内皮生长因子和转化生长因子等主要生长因子的表达明显高于市售敷料。上调对皮肤的重塑也有很好的效果。本研究制备的伤口敷料对伤口愈合的各个阶段都有很好的效果，对慢性伤口的愈合很重要。它为伤口愈合提供了更多选择，特别是慢性伤口愈合。

更新日期：2020-12-14

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