Emerging Trends in Nanomedicine for Improving Ocular Drug Delivery: Light-Responsive Nanoparticles, Mesoporous Silica Nanoparticles, and Contact Lenses,ACS Biomaterials Science & Engineering

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Emerging Trends in Nanomedicine for Improving Ocular Drug Delivery: Light-Responsive Nanoparticles, Mesoporous Silica Nanoparticles, and Contact Lenses
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-12-02 , DOI: 10.1021/acsbiomaterials.0c01347
Flávia S. C. Rodrigues _{1,

2,

3} , António Campos _{1,

2,

3,

4,

5} , João Martins _{1,

2,

3,

6,

7} , António Francisco Ambrósio _{1,

2,

3,

8} , Elisa J. Campos _{1,

2,

3,

8}

Affiliation

Vision is the most dominant of our senses, and it is crucial in every stage of our lives. Ocular diseases, regardless of whether they cause vision impairment or not, lead to personal and financial hardships. The anatomy and physiology of the eye strongly limit the efficacy of current ocular drug delivery strategies. Nanotechnology has been the ground for the development of powerful strategies in several fields, namely in medicine. This review highlights emerging nanotechnology-based solutions for improving ocular drug delivery and thus the bioavailability and efficacy of drugs. We focus our review on ambitious but promising approaches currently emerging to leverage the efficacy of nanoparticle-based systems in ocular therapy: (i) light-responsive nanoparticles, which enable spatiotemporal control of drug release; (ii) mesoporous silica nanoparticles, which offer high surface area-to-volume ratio, simple surface modification, good biocompatibility, and improved bioavailability; and (iii) contact lenses, which serve as a compliant method of nanoparticles use and as drug delivery systems for the treatment of ocular diseases.

中文翻译：

改善眼用药物递送的纳米药物的新兴趋势：光响应性纳米颗粒，中孔二氧化硅纳米颗粒和隐形眼镜

视觉是我们感官中最主要的，并且在我们生活的每个阶段都至关重要。眼部疾病，无论是否引起视力障碍，都会导致个人和财务困难。眼睛的解剖学和生理学强烈限制了当前眼部药物递送策略的功效。纳米技术一直是在多个领域（例如医学领域）开发强大策略的基础。这篇综述重点介绍了基于纳米技术的新兴解决方案，这些解决方案可改善眼部药物的输送，从而改善药物的生物利用度和功效。我们的综述集中在目前正在涌现的雄心勃勃但有希望的方法，以利用基于纳米颗粒的系统在眼科治疗中的功效：（i）光响应纳米颗粒，能够实现时空控制药物释放；（ii）中孔二氧化硅纳米颗粒，其具有高的表面积体积比，简单的表面改性，良好的生物相容性和改善的生物利用度；（iii）隐形眼镜，用作纳米颗粒的顺应性使用方法和治疗眼疾病的药物递送系统。

更新日期：2020-12-14

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