Dynamic and conformational switching in proteins,Biopolymers

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Dynamic and conformational switching in proteins
Biopolymers ( IF 3.2 ) Pub Date : 2020-12-03 , DOI: 10.1002/bip.23411
H A Scheraga ₁ , S Rackovsky _{1,

2}

Affiliation

Using bioinformatic methods for treating protein dynamics, developed in earlier work, we study the relationship between sequence mobility and dynamics in proteins. It is shown that sequence mobility drives a transition between two dynamic regimes in proteins, and that the specific details of this transition differ qualitatively between α-helical proteins and those in other structural classes. We examine the possibility that conformational switching is related to dynamic switching, by considering a specific system of sequences which exhibit the switching phenomenon. It is shown that a relationship between dynamic and conformational switching is entirely plausible.

中文翻译：

蛋白质的动态和构象转换

使用早期工作中开发的处理蛋白质动力学的生物信息学方法，我们研究了蛋白质中序列迁移性和动力学之间的关系。结果表明，序列迁移性驱动蛋白质中两种动态状态之间的转变，并且这种转变的具体细节在 α-螺旋蛋白质和其他结构类别的蛋白质之间有质的不同。通过考虑表现出切换现象的特定序列系统，我们研究了构象切换与动态切换相关的可能性。结果表明，动态和构象转换之间的关系是完全合理的。

更新日期：2020-12-03

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