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Silenced SOX2‐OT alleviates ventricular arrhythmia associated with heart failure by inhibiting NLRP3 expression via regulating miR‐2355‐3p
Immunity, Inflammation and Disease ( IF 3.1 ) Pub Date : 2020-12-03 , DOI: 10.1002/iid3.388 Yuming Liang 1 , Boqun Wang 1 , Huijuan Huang 1 , Maoyun Wang 1 , Qianwen Wu 1 , Yaxin Zhao 1 , Yan He 1
Immunity, Inflammation and Disease ( IF 3.1 ) Pub Date : 2020-12-03 , DOI: 10.1002/iid3.388 Yuming Liang 1 , Boqun Wang 1 , Huijuan Huang 1 , Maoyun Wang 1 , Qianwen Wu 1 , Yaxin Zhao 1 , Yan He 1
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Nucleotide‐binding oligomerization domain‐like receptor family pyrin domain containing 3 (NLRP3) inflammasomes are the most important factors in ventricular arrhythmia associated with heart failure (VA‐HF). However, how the relationship between lncRNA and NLRP3 inflammasomes is regulated in VA‐HF has not been investigated in detail. Thus, we aimed to determine the effects of SOX2‐overlapping transcripts (SOX2‐OT) by targeting NLRP3 in rats with VA‐HF.
中文翻译：
沉默的SOX2-OT通过调节miR-2355-3p抑制NLRP3表达减轻与心力衰竭相关的室性心律失常
核苷酸结合寡聚化结构域样受体家族 pyrin 结构域包含 3 个（NLRP3）炎性体是与心力衰竭相关的室性心律失常（VA-HF）的最重要因素。然而，在 VA-HF 中 lncRNA 和 NLRP3 炎症小体之间的关系如何被调节尚未详细研究。因此，我们旨在通过在 VA-HF 大鼠中靶向 NLRP3 来确定 SOX2 重叠转录物（SOX2-OT）的影响。
更新日期：2021-02-04
中文翻译：
沉默的SOX2-OT通过调节miR-2355-3p抑制NLRP3表达减轻与心力衰竭相关的室性心律失常
核苷酸结合寡聚化结构域样受体家族 pyrin 结构域包含 3 个（NLRP3）炎性体是与心力衰竭相关的室性心律失常（VA-HF）的最重要因素。然而，在 VA-HF 中 lncRNA 和 NLRP3 炎症小体之间的关系如何被调节尚未详细研究。因此，我们旨在通过在 VA-HF 大鼠中靶向 NLRP3 来确定 SOX2 重叠转录物（SOX2-OT）的影响。
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