Dec2 attenuates autophagy in inflamed periodontal tissues,Immunity, Inflammation and Disease

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Dec2 attenuates autophagy in inflamed periodontal tissues
Immunity, Inflammation and Disease ( IF 3.1 ) Pub Date : 2020-12-03 , DOI: 10.1002/iid3.389
Shunichi Oka _{1,

2} , Xiaoyan Li ₃ , Fuyuki Sato ₄ , Fengzhu Zhang ₅ , Nitesh Tewari ₆ , Chongchong Chen ₇ , Liangjun Zhong ₇ , Makoto Makishima ₈ , Yi Liu ₃ , Ujjal K Bhawal _{9,

10}

Affiliation

Department of Anesthesiology, Nihon University School of Dentistry, Tokyo, Japan.
Division of Immunology and Pathology, Dental Research Center, Nihon University School of Dentistry, Tokyo, Japan.
Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, People's Republic of China.
Pathology Division, Shizuoka Cancer Center, Shizuoka, Japan.
Department of Anesthesiology, Nihon University School of Dentistry at Matsudo, Chiba, Japan.
Division of Pedodontics and Preventive Dentistry, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India.
Department of Stomatology, Hangzhou Normal University, Hangzhou, People's Republic of China.
Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo, Japan.
Department of Disaster Medicine and Dental Sociology, Kanagawa Dental University, Yokosuka, Japan.
Department of Biochemistry and Molecular Biology, Nihon University School of Dentistry at Matsudo, Chiba, Japan.

Transcriptional regulation of autophagy depends on the transcription factors coordinated inflammatory feedback mechanism. Here, we provide a comprehensive functional characterization of periodontal ligament fibroblasts (PDLFs) treated with Porphyromonas gingivalis lipopolysaccharide (LPS), aiming to reveal previously unappreciated biological changes and to investigate how a transcription factor differentiated embryonic chondrocytes 2 (Dec2)‐deficient environment influences the function of autophagy in nflamed human PDLFs.

中文翻译：

Dec2 减弱发炎牙周组织中的自噬

自噬的转录调控依赖于转录因子协调的炎症反馈机制。在这里，我们提供了用牙龈卟啉单胞菌脂多糖（LPS）处理的牙周膜成纤维细胞（PDLF）的全面功能表征，旨在揭示以前未被重视的生物学变化，并研究转录因子分化胚胎软骨细胞2（Dec2）缺陷环境如何影响牙周膜成纤维细胞（PDLF）的功能。发炎的人 PDLF 中自噬的功能。

更新日期：2021-02-04

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