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A Hydrophobic‐Interaction‐Based Mechanism Triggers Docking between the SARS‐CoV‐2 Spike and Angiotensin‐Converting Enzyme 2 (Global Challenges 12/2020)
Global Challenges ( IF 4.4 ) Pub Date : 2020-12-03 , DOI: 10.1002/gch2.202070121
Jiacheng Li 1 , Xiaoliang Ma 1 , Shuai Guo 1 , Chengyu Hou 2 , Liping Shi 1 , Hongchi Zhang 1 , Bing Zheng 3 , Chenchen Liao 2 , Lin Yang 1, 4 , Lin Ye 4 , Xiaodong He 1, 5
Affiliation  

In article number 2000067 Lin Yang and co‐workers find that the hydrophobic interaction between the SARS‐CoV‐2 spike protein and the ACE2 protein is significantly greater than that between the SARS‐CoV spike protein and the ACE2 protein. At the docking site, the hydrophobic portions of the hydrophilic side chains of SARS‐CoV‐2 S are found to be involved in the hydrophobic interaction between the SARS‐CoV‐2 spike protein and ACE2.
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中文翻译:

基于疏水相互作用的机制触发了SARS-CoV-2尖峰和血管紧张素转化酶2之间的对接(全球挑战12/2020)

Lin Yang和同事在文章编号2000067中发现,SARS-CoV-2刺突蛋白与ACE2蛋白之间的疏水相互作用显着大于SARS-CoV刺突蛋白与ACE2蛋白之间的疏水相互作用。在对接位点,SARS-CoV-2 S亲水性侧链的疏水部分被发现与SARS-CoV-2尖峰蛋白和ACE2之间的疏水相互作用有关。
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更新日期:2020-12-03
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