Development of pluripotent stem cell‐based human tenocytes,Development, Growth & Differentiation

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Development of pluripotent stem cell‐based human tenocytes
Development, Growth & Differentiation ( IF 1.7 ) Pub Date : 2020-12-03 , DOI: 10.1111/dgd.12702
Taiki Nakajima _{1,

2,

3} , Makoto Ikeya ₁

Affiliation

Human pluripotent stem cells (PSCs) are used as a platform for therapeutic purposes such as cell transplantation therapy and drug discovery. Another motivation for studying PSCs is to understand human embryogenesis and development. All cell types that make up the body tissues develop through defined trajectories during embryogenesis. For example, paraxial mesoderm is considered to differentiate into several cell types including skeletal muscle cells, chondrocytes, osteocytes, dermal fibroblasts, and tenocytes. Tenocytes are fibroblast cells that constitute the tendon. The step‐wise narrowing fate decisions of paraxial mesoderm in the embryo have been modeled in vitro using PSCs; however, deriving tenocytes from human‐induced PSCs and their application in cell therapy have long been challenging. PSC‐derived tenocytes can be used for a source of cell transplantation to treat a damaged or ruptured tendon due to injury, disorder, or aging. In this review, we discuss the latest research findings on the use of PSCs for studying the biology of tenocyte development and their application in therapeutic settings.

中文翻译：

基于多能干细胞的人肌腱细胞的开发

人类多能干细胞 (PSC) 被用作治疗目的的平台，例如细胞移植治疗和药物发现。研究 PSC 的另一个动机是了解人类胚胎的发生和发育。构成身体组织的所有细胞类型都在胚胎发生过程中通过确定的轨迹发育。例如，近轴中胚层被认为可分化为多种细胞类型，包括骨骼肌细胞、软骨细胞、骨细胞、真皮成纤维细胞和肌腱细胞。肌腱细胞是构成肌腱的成纤维细胞。胚胎中轴旁中胚层的逐步缩小命运决定已在体外使用 PSC 进行建模；然而，从人类诱导的 PSC 中提取肌腱细胞及其在细胞治疗中的应用长期以来一直具有挑战性。PSC 衍生的肌腱细胞可用作细胞移植的来源，以治疗因损伤、紊乱或老化而受损或破裂的肌腱。在这篇综述中，我们讨论了关于使用 PSC 研究肌腱细胞发育生物学及其在治疗环境中的应用的最新研究成果。

更新日期：2020-12-03

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