Chemoreactive Nanotherapeutics by Metal Peroxide Based Nanomedicine,Advanced Science

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Chemoreactive Nanotherapeutics by Metal Peroxide Based Nanomedicine
Advanced Science ( IF 14.3 ) Pub Date : 2020-12-03 , DOI: 10.1002/advs.202000494
Hui Hu _{1,

2} , Luodan Yu ₃ , Xiaoqin Qian ₁ , Yu Chen ₃ , Baoding Chen ₄ , Yuehua Li ₂

Affiliation

The advances of nanobiotechnology and nanomedicine enable the triggering of in situ chemical reactions in disease microenvironment for achieving disease‐specific nanotherapeutics with both intriguing therapeutic efficacy and mitigated side effects. Metal peroxide based nanoparticles, as one of the important but generally ignored categories of metal‐involved nanosystems, can function as the solid precursors to produce oxygen (O₂) and hydrogen peroxide (H₂O₂) through simple chemical reactions, both of which are the important chemical species for enhancing the therapeutic outcome of versatile modalities, accompanied with the unique bioactivity of metal ion based components. This progress report summarizes and discusses the most representative paradigms of metal peroxides in chemoreactive nanomedicine, including copper peroxide (CuO₂), calcium peroxide (CaO₂), magnesium peroxide (MgO₂), zinc peroxide (ZnO₂), barium peroxide (BaO₂), and titanium peroxide (TiO_x) nanosystems. Their reactions and corresponding products have been broadly explored in versatile disease treatments, including catalytic nanotherapeutics, photodynamic therapy, radiation therapy, antibacterial infection, tissue regeneration, and some synergistically therapeutic applications. This progress report particularly focuses on the underlying reaction mechanisms on enhancing the therapeutic efficacy of these modalities, accompanied with the discussion on their biological effects and biosafety. The existing gap between fundamental research and clinical translation of these metal peroxide based nanotherapeutic technologies is finally discussed in depth.

中文翻译：

基于金属过氧化物的纳米药物的化学活性纳米疗法

纳米生物技术和纳米医学的进步使得能够在疾病微环境中触发原位化学反应，从而实现疾病特异性纳米治疗，同时具有令人着迷的治疗功效和减轻的副作用。金属过氧化物基纳米粒子是重要但通常被忽视的金属纳米系统类别之一，可以作为固体前体通过简单的化学反应产生氧气（O ₂）和过氧化氢（H ₂ O ₂），这两种反应是增强多种治疗方法治疗效果的重要化学物质，同时具有基于金属离子的成分的独特生物活性。本进展报告总结并讨论了化学活性纳米药物中最具代表性的金属过氧化物范例，包括过氧化铜（CuO ₂）、过氧化钙（CaO ₂）、过氧化镁（MgO ₂）、过氧化锌（ZnO ₂）、过氧化钡（BaO）₂ ) 和过氧化钛 (TiO _x ) 纳米系统。它们的反应和相应的产物已在多种疾病治疗中得到广泛探索，包括催化纳米疗法、光动力疗法、放射疗法、抗菌感染、组织再生和一些协同治疗应用。本进展报告特别关注增强这些方式治疗功效的潜在反应机制，并讨论其生物学效应和生物安全性。最后深入讨论了这些基于金属过氧化物的纳米治疗技术的基础研究和临床转化之间存在的差距。

更新日期：2021-01-07

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