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Limb Development: Atlas of Musculoskeletal Stem Cells with the Soft and Hard Tissue Differentiation Architecture (Adv. Sci. 23/2020)
Advanced Science ( IF 14.3 ) Pub Date : 2020-12-02 , DOI: 10.1002/advs.202070129
Zi Yin , Junxin Lin , Ruojin Yan , Richun Liu , Mengfei Liu , Bo Zhou , Wenyan Zhou , Chengrui An , Yangwu Chen , Yejun Hu , Chunmei Fan , Kun Zhao , Bingbing Wu , Xiaohui Zou , Jin Zhang , Ahmed H. El‐Hashash , Xiao Chen , Hongwei Ouyang

In article number 2000938, Zi Yin, Junxin Lin, and co‐workers identify a novel musculoskeletal stem cell population by single‐cell transcriptional profiling with lineage tracing data during limb development. The differentiation potential and trajectory of musculoskeletal stem cells showed they could contribute to soft and hard connective tissues, as well as muscular tissue. These results suggest an indispensable role of limb Scx+ musculoskeletal stem cell population in musculoskeletal system morphogenesis.
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中文翻译:

肢体发育:具有软组织和硬组织分化结构的肌肉骨骼干细胞图集(Adv。Sci。23/2020)

在第2000938号文章中,Zi Yin,Linxin Lin和同事们通过肢体发育过程中沿袭谱系数据的单细胞转录谱分析鉴定了一种新型的肌肉骨骼干细胞群体。肌肉骨骼干细胞的分化潜能和轨迹表明,它们可以促进软,硬结缔组织以及肌肉组织。这些结果表明,肢体Scx +肌肉骨骼干细胞群体在肌肉骨骼系统形态发生中起着不可或缺的作用。
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更新日期:2020-12-03
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