Air pollution represents one of the main risks for both environment and human health. The rapid urbanization has been leading to a continuous release of harmful manmade substances into the atmosphere which are associated to the exacerbation of several pathologies. The skin is the main barrier of our body against the external environment and it is the main target for the outdoor stressors. Among the pollutants, Ozone (O3) is one of the most toxic, able to initiate oxidative reactions and activate inflammatory response, leading to the onset of several skin conditions. Moreover, skin is daily subjected to the activity of Ultraviolet Radiation which are well known to induce harmful cutaneous effects including skin aging and sunburn. Even though both UV and O3 are able to affect the skin homeostasis, very few studies have investigated their possible additive effect. Therefore, in this study we evaluated the effect of the combined exposure of O3 and UV in inducing skin damage, by exposing human skin explants to UV alone or in combination with O3 for 4-days. Markers related to inflammation, redox homeostasis and tissue structure were analyzed. Our results demonstrated that O3 is able to amplify the UV induced skin oxinflammation markers.

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评估臭氧在紫外线引起的皮肤损伤中的作用

空气污染是环境和人类健康的主要风险之一。快速的城市化导致有害的人造物质不断释放到大气中，这与多种疾病的恶化有关。皮肤是我们身体抵御外部环境的主要屏障，也是户外压力源的主要目标。在污染物中，臭氧 (O3) 是毒性最大的污染物之一，能够引发氧化反应并激活炎症反应，导致多种皮肤病的发作。此外，皮肤每天都会受到紫外线辐射的影响，众所周知，紫外线辐射会导致有害的皮肤影响，包括皮肤老化和晒伤。即使紫外线和 O3 都能影响皮肤稳态，很少有研究调查它们可能的累加效应。因此，在这项研究中，我们通过将人类皮肤外植体单独暴露于紫外线或与 O3 组合暴露 4 天，评估了 O3 和紫外线联合暴露对诱导皮肤损伤的影响。分析了与炎症、氧化还原稳态和组织结构相关的标志物。我们的结果表明，O3 能够放大紫外线引起的皮肤炎症标志物。