Studies of how intravenously injected nanoparticles (NPs) enter tumours and are taken up by tumour cells have been discussed for more than three decades. Despite this, we still have much to learn about interactions between NPs and how they can be transported across the endothelial cell layer. More studies are required before firm conclusions can be drawn regarding the contribution of passive or energy dependent mechanisms for transport of NPs over the endothelial cells allowing the NPs to reach solid tumours.

中文翻译：

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纳米颗粒穿过内皮细胞层的运输

关于静脉注射纳米颗粒 (NP) 如何进入肿瘤并被肿瘤细胞吸收的研究已经讨论了三十多年。尽管如此，关于纳米粒子之间的相互作用以及它们如何跨内皮细胞层运输，我们仍然有很多东西需要了解。关于被动或能量依赖性机制对纳米粒子在内皮细胞上的运输从而使纳米粒子到达实体瘤的贡献，需要进行更多的研究才能得出明确的结论。