In the present study, a sensitive and specific electrochemical sensor is developed based on titanium dioxide and ionic liquid nano-composite (TiO₂NPs/IL) for the measurement of Zolpidem (ZLP) as a hypnotic and sleep-promoting drug. The nano-composite provides high surface area and catalytic ability in ZLP oxidation at the modified carbon paste electrode (CPE). The obtained results of the differential pulse voltammetry (DPV) method reflect a wide linear range (0.1−90 μM) and an unprecedented limit of detection (LOD = 33 nM) for the ZLP sensor comparable with previously reported methods. The TiO₂NPs/IL/CPE remarkably enriched the electrochemical response to ZLP oxidation and it has good stability, repeatability, and reproducibility. The TiO₂NPs/IL/CPE is mechanically stable, cost-effective and simple, with suitable electrochemical and adsorption properties in comparison to the pencil graphite electrode (PGE) and glassy carbon electrode (GCE). The potential applicability of the sensor was successfully applied for distinguishing the ZLP in human plasma and drug formulation samples.

在本研究中，基于二氧化钛和离子液体纳米复合材料（TiO ₂ NPs / IL）开发了一种灵敏而特定的电化学传感器，用于测量作为催眠和睡眠促进药物的唑吡坦（ZLP）。纳米复合材料在改性碳糊电极（CPE）上的ZLP氧化中提供了高表面积和催化能力。与先前报道的方法相比，ZLP传感器的差分脉冲伏安法（DPV）方法获得的结果反映了宽的线性范围（0.1-90μM）和前所未有的检测极限（LOD = 33 nM）。TiO ₂ NPs / IL / CPE显着丰富了对ZLP氧化的电化学反应，并具有良好的稳定性，可重复性和可重复性。TiO ₂与笔形石墨电极（PGE）和玻璃碳电极（GCE）相比，NPs / IL / CPE具有机械稳定性，成本效益和简单性，并具有合适的电化学和吸附性能。该传感器的潜在适用性已成功应用于区分人血浆和药物制剂样品中的ZLP。