Antioxidant supplementation and physical exercise have been discussed as strategies to minimize neurodegeneration in Alzheimer's disease (AD). We investigated the neuroprotective effects of strength exercise (StrEx) and green tea (GT) supplementation, combined or not, on memory impairments induced by β-amyloid characterizing an AD-like condition in rats. Wistar rats were submitted to 8 weeks of StrEx, GT supplementation, or StrEx and GT combined. AD-like condition was induced by injection of Aβ (25–35) in the hippocampus. We evaluate object recognition (OR) and social recognition (SR) memory, and removed the rats' hippocampus for biochemical analysis. StrEx improved OR and SR. StrEx combined with GT improved OR and did not improve SR. GT reduced antioxidant capacity and improved acetylcholinesterase activity. Both strength exercise and green tea are neuroprotective against impairments resultant of β-amyloid, but benefits do not add up when the two interventions are associated.

已经讨论了抗氧化剂补充和体育锻炼作为最小化阿尔茨海默氏病（AD）中神经退行性变的策略。我们调查了力量运动（StrEx）和绿茶（GT）的添加，无论是否组合，对大鼠β-淀粉样蛋白所致AD记忆障碍的神经保护作用。Wistar大鼠接受了8周的StrEx，GT补充或StrEx和GT合并治疗。通过在海马中注射Aβ（25–35）诱发AD样疾病。我们评估对象识别（OR）和社交识别（SR）记忆，并删除大鼠海马进行生化分析。StrEx改进了OR和SR。StrEx与GT的结合改善了OR，并没有改善SR。GT降低了抗氧化能力并提高了乙酰胆碱酯酶活性。