Human’s uncertain decision-making involves choices of risk (with known probabilities) and ambiguity (with unknown probabilities). For risky and ambiguous decision-making processes, neural differences are rarely exhibited. To clarify the causal role of the right dorsolateral prefrontal cortex (DLPFC) in uncertain situations, we used transcranial direct current stimulation (tDCS) to demonstrate the involvement of the right DLPFC in decisions involving risk and ambiguity. Participants received either anodal or cathodal tDCS at 1.5 mA or sham stimulation over the right DLPFC and subsequently undertook tasks of risk and ambiguity. The results revealed that a preference for ambiguity could be measurably increased in individuals through anodal stimulation, but no significant differences were observed in the preferences for risky choices among groups. These findings suggest that different neural mechanisms underlie risky and ambiguous decisions because the right DLPFC primarily affects ambiguous behavior.

人类的不确定性决策涉及风险（概率已知）和模糊（概率未知）的选择。对于有风险和模棱两可的决策过程，很少表现出神经差异。为了阐明右侧背外侧前额叶皮层 (DLPFC) 在不确定情况下的因果作用，我们使用经颅直流电刺激 (tDCS) 来证明右侧 DLPFC 参与涉及风险和模糊性的决策。参与者在右侧 DLPFC 上接受 1.5 mA 的阳极或阴极 tDCS 或假刺激，随后承担了风险和不确定性的任务。结果表明，通过阳极刺激可以显着增加个体对歧义的偏好，但在各组之间对风险选择的偏好没有观察到显着差异。