Our understanding of vitamin D has improved considerably in recent years. The role of vitamin D in preventing osteoporotic fractures is now well-established. However, an important controversy has emerged in the last decade concerning the effects of the active form of vitamin D (1,25-dihydroxy-vitamin D) on tissues other than bone (non-classical effects). The demonstration that the vitamin D receptor (VDR) is ubiquitously, expressed combined with increasing observational data supporting a relationship between the level of 25-hydroxy-vitamin D in the serum and chronic metabolic disorders, cardiovascular disease and neoplasms, have led to its redefinition as a steroid hormone and the proposal of its use in preventing and/or treating those diseases. This article is an update on the different non-bone or non-classical effects of “vitamin-hormone D”, and its potential preventive or therapeutic role in certain diseases, however, this review is not exhaustive. The different modalities of substitution or supplementation proposed in France by the Groupe de Recherche et d’Information sur les Ostéoporoses (GRIO) are also summarised.

近年来，我们对维生素 D 的理解有了很大的提高。维生素 D 在预防骨质疏松性骨折方面的作用现已得到公认。然而，在过去十年中出现了关于活性形式的维生素 D（1,25-二羟基维生素 D）对骨骼以外组织的影响（非经典效应）的重要争议。证明维生素 D 受体 (VDR) 无处不在，并结合越来越多的观察数据支持血清中 25-羟基维生素 D 水平与慢性代谢紊乱、心血管疾病和肿瘤之间的关系，导致其重新定义作为类固醇激素及其在预防和/或治疗这些疾病中的用途的提议。本文是对“维生素-激素 D”不同非骨或非经典作用的更新，及其在某些疾病中的潜在预防或治疗作用，但是，本综述并不详尽。还总结了 Groupe de Recherche et d'Information sur les Ostéoporoses (GRIO) 在法国提出的不同替代或补充方式。