A new method for the preparation of isoxazolylvinyl ketones related to potential cytotoxic agents has been developed. In the first step, the reaction of furfuryl ketones with hydroxylamine hydrochloride affords the corresponding oximes. Further, the oxidative ring opening – ring closure reaction of oximes leads to isoxazoles with an α, β-unsaturated carbonyl motif. The developed procedure is metal-free and does not require expensive starting materials.

中文翻译：

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取代呋喃合成异恶唑基乙烯基酮

已开发出一种新的制备与潜在细胞毒性剂有关的异恶唑基乙烯基酮的方法。在第一步中，糠基酮与羟胺盐酸盐的反应得到相应的肟。此外，肟的氧化开环-闭环反应会生成具有α，β-不饱和羰基的异恶唑。开发的程序不含金属，不需要昂贵的原材料。