Purpose of Review

Migraine remains a challenging condition to treat, thus highlighting the need for a better understanding of its molecular mechanisms. This review intends to unravel a new emerging target in migraine pathophysiology, the adenosine 5′-triphosphate-sensitive K⁺ (K_ATP) channel.

Recent Findings

K_ATP channel is a common denominator in the cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) mediated intracellular cascades, both of which are involved in migraine. Intravenous infusion of K_ATP channel opener, levcromakalim, provoked migraine attack associated with dilation of extracerebral arteries in all persons with migraine.

Summary

Preclinical and clinical studies implicate K_ATP channels in migraine initiation. K_ATP channel is a novel therapeutic target for the acute and preventive treatment of migraine. Future studies are warranted to provide a better understanding of the role of K_ATP channel subgroups in migraine.

中文翻译：

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偏头痛病理生理学的最新见解：ATP 敏感的钾通道

审查目的

偏头痛仍然是一种具有挑战性的疾病，因此强调需要更好地了解其分子机制。本综述旨在揭示偏头痛病理生理学中的一个新目标，即腺苷 5'-三磷酸敏感 K ⁺ (K _ATP ) 通道。

最近的发现

K _ATP通道是环磷酸腺苷 (cAMP) 和环磷酸鸟苷 (cGMP) 介导的细胞内级联反应的共同点，这两者都与偏头痛有关。静脉输注 K _ATP通道开放剂，levcromakalim，在所有偏头痛患者中引发与脑外动脉扩张相关的偏头痛发作。

概括

临床前和临床研究表明 K _ATP通道与偏头痛的发生有关。K _ATP通道是偏头痛急性和预防性治疗的新治疗靶点。未来的研究有必要更好地了解 K _ATP通道亚群在偏头痛中的作用。