In 3 months after infection with Mycobacterium tuberculosis (MBT) from BCG vaccine, male BALB/с mice received intraperitoneal injections of isonicotinic acid hydrazide, dextrazide, or liposome-encapsulated dextrazide, or inhalation of liposome-encapsulated dextrazide 2 times a week for 6 months. In 6 months, no MBT were detected in macrophages outside granulomas in treated mice. Macrophages containing MBT can incorporate into granulomas and leave them after suppression of MBT persistence. Liposome-encapsulated dextrazide showed the maximum therapeutic efficiency: the total MBT level in granuloma macrophages and volume density of destruction foci in the liver parenchyma decreased by 5.1 and 5.3 times, respectively, in comparison with the corresponding parameters in mice treated with isonicotinic acid hydrazide. Inhalations of liposome-encapsulated dextrazide prevented the destructive processes in liver granulomas due to macrophage migration from granulomas, which reduced granuloma sizes and destructive potential of granuloma lysosomes and therefore improved their diffusion-dependent trophics.

中文翻译：

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不同抗结核药物的疗效分析及治疗卡介苗诱导的小鼠肉芽肿和肝脏结核分枝杆菌的丰度和定位的方法

在卡介苗疫苗感染结核分枝杆菌 (MBT) 后 3 个月内，雄性 BALB/с 小鼠接受腹腔注射异烟酸酰肼、右旋肼或脂质体包裹的右嗪，或吸入脂质体包裹的右嗪，每周 2 次，持续 6 个月. 在 6 个月内，在接受治疗的小鼠肉芽肿外的巨噬细胞中未检测到 MBT。含有 MBT 的巨噬细胞可以合并到肉芽肿中，并在抑制 MBT 持久性后离开它们。脂质体包裹的右旋肼显示出最大的治疗效率：与异烟酸酰肼治疗的小鼠的相应参数相比，肉芽肿巨噬细胞中的总 MBT 水平和肝实质破坏灶的体积密度分别降低了 5.1 倍和 5.3 倍。