We studied the involvement of NMDA glutamate receptors in the mechanisms of anterograde amnesia. It was found that repeated training of amnestic animals treated with D-cycloserine, a potent agonist of the glycine site of NMDA receptors, did not lead to consolidation of long-term memory, while expression of short-term memory was more pronounced in comparison with control animals that received saline before repeated training. It was shown that D-cycloserine in amnestic snails did not affect the food reactions caused by the presentation of a conditioned stimulus during the reminder (without combination with the unconditioned stimulus). It is assumed that NMDA glutamate receptors in amnestic animals are involved in the neural plasticity mechanisms that underlie short-term memory, but their activation does not influence the anterograde amnesia processes and does not lead to the formation or recovery of long-term memory.

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NMDA 谷氨酸受体参与特定顺行性遗忘逆转机制的研究

我们研究了 NMDA 谷氨酸受体参与顺行性遗忘症的机制。结果发现，用 NMDA 受体甘氨酸位点的强效激动剂 D-环丝氨酸治疗的遗忘动物的重复训练不会导致长期记忆的巩固，而短期记忆的表达与在重复训练前接受盐水的对照动物。结果表明，健忘蜗牛中的 D-环丝氨酸不会影响在提醒期间出现条件刺激（不与无条件刺激相结合）引起的食物反应。据推测，健忘症动物中的 NMDA 谷氨酸受体参与了构成短期记忆基础的神经可塑性机制，