Mycobacterium vaccae is a soil saprophyte which exerts anti-allergic properties. There are data that mechanism of action of M. vaccae when used in the treatment of human and animal allergic diseases is associated with Th1-phenotype switch. Here we studied the properties of sonicated M. vaccae lysate in co-cultures of dendritic cells and CD4+T cells. M. vaccae lysate stimulated IL-10 synthesis in co-cultures and CD86 expression in dendritic cells, being more potent than heat-killed M. vaccae. The reported clinical data and the mechanism of action of M. vaccae lysate suggest that its use is a feasible option for the primary prevention of allergic diseases, in particular atopic dermatitis.

中文翻译：

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母牛分枝杆菌裂解物在体外诱导抗过敏免疫反应

母牛分枝杆菌是一种土壤腐生菌，具有抗过敏特性。有数据表明母牛分枝杆菌用于治疗人和动物过敏性疾病的作用机制与 Th1 表型转换有关。在这里，我们研究了超声处理的母牛分枝杆菌裂解物在树突细胞和 CD4+T 细胞的共培养物中的特性。母牛分枝杆菌裂解物刺激共培养物中的 IL-10 合成和树突细胞中的 CD86 表达，比热杀死的母牛分枝杆菌更有效。已报告的临床数据和母牛分枝杆菌裂解物的作用机制表明，其使用是过敏性疾病，特别是特应性皮炎的一级预防的可行选择。