Background Patients with eating disorders may experience a severe and enduring course of illness. Treatment outcome for patients provided with inpatient treatment is reported as poor. Research to date has not provided consistent results for predictors of treatment outcome. The aims of the study were to investigate rates of remission at follow-up after inpatient treatment, symptom change from admission to follow-up, and predictors of treatment outcome. Methods The follow-up sample consisted of 150 female adult former patients (69.4% of all eligible female patients) with eating disorders. Mean age at admission was 21.7 (SD = 4.9) years. Diagnostic distribution: 66% (n = 99) anorexia nervosa, 21.3% (n = 32) bulimia nervosa and 12.7% (n = 19) other specified feeding or eating disorder, including binge eating. Data were collected at admission, discharge and follow-up (mean 2.7 (SD = 1.9) years). Definition of remission was based on the EDE-Q Global score, body mass index and binge/purge behavior. Paired T-tests were performed to investigate change over time. Univariate and multivariate logistic regressions were estimated to investigate predictors of remission. Results At follow-up, 35.2% of the participants were classified as in remission. Significant symptom reduction (in all patients) (p < 0.001) and significant increase in body mass index (BMI) (in underweight participants at admission) (p < 0.001) was found. Increased BMI (p < 0.05), the level of core eating disorder symptoms at admission (p < 0.01) and reduced core eating disorder symptoms (p < 0.01) during inpatient treatment were found significant predictors of outcome in the multivariate model. Conclusions All participants had an eating disorder requiring inpatient treatment. Approximately one-third of all participants could be classified as in remission at follow-up. However, most participants experienced significant symptom improvement during inpatient treatment and the improvements were sustained at follow-up. Increased probability of remission at follow-up was indicated by lower core ED symptoms at admission for all patients, raised BMI during admission for patients with AN, and reduced core ED symptoms during inpatient treatment for all patients. This finding contributes important information and highlights the importance of targeting these core symptoms in transdiagnostic treatment programs.

中文翻译：

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住院饮食失调治疗后的随访结果：一项自然主义研究

背景 饮食失调患者可能会经历严重且持久的病程。据报道，接受住院治疗的患者的治疗结果很差。迄今为止的研究尚未为治疗结果的预测提供一致的结果。该研究的目的是调查住院治疗后随访的缓解率、从入院到随访的症状变化以及治疗结果的预测因素。方法 随访样本包括 150 名患有进食障碍的成年女性患者（占所有符合条件的女性患者的 69.4%）。入院时的平均年龄为 21.7 (SD = 4.9) 岁。诊断分布：66% (n = 99) 神经性厌食症，21.3% (n = 32) 神经性贪食症和 12.7% (n = 19) 其他特定的进食或进食障碍，包括暴食。入院时收集数据，出院和随访（平均 2.7 (SD = 1.9) 年）。缓解的定义基于 EDE-Q 全球评分、体重指数和暴饮暴食/清除行为。进行配对 T 检验以研究随时间的变化。估计单变量和多变量逻辑回归以研究缓解的预测因素。结果 在随访中，35.2% 的参与者被归类为缓解。发现症状显着减少（在所有患者中）（p < 0.001）和体重指数（BMI）显着增加（入院时体重不足的参与者）（p < 0.001）。在多变量模型中发现，BMI 增加（p < 0.05）、入院时核心进食障碍症状水平（p < 0.01）和住院治疗期间核心进食障碍症状减少（p < 0.01）是预后的重要预测因子。结论 所有参与者都患有需要住院治疗的饮食失调症。大约三分之一的参与者在随访时可归类为缓解。然而，大多数参与者在住院治疗期间经历了显着的症状改善，并且在随访中持续改善。所有患者入院时核心 ED 症状降低，AN 患者入院期间 BMI 升高，以及所有患者住院治疗期间核心 ED 症状减少，表明随访时缓解的可能性增加。这一发现提供了重要信息，并强调了在跨诊断治疗计划中针对这些核心症状的重要性。大约三分之一的参与者在随访时可归类为缓解。然而，大多数参与者在住院治疗期间经历了显着的症状改善，并且在随访中持续改善。所有患者入院时核心 ED 症状降低，AN 患者入院期间 BMI 升高，以及所有患者住院治疗期间核心 ED 症状减少，表明随访时缓解的可能性增加。这一发现提供了重要信息，并强调了在跨诊断治疗计划中针对这些核心症状的重要性。大约三分之一的参与者在随访时可归类为缓解。然而，大多数参与者在住院治疗期间经历了显着的症状改善，并且在随访中持续改善。所有患者入院时核心 ED 症状降低，AN 患者入院期间 BMI 升高，以及所有患者住院治疗期间核心 ED 症状减少，表明随访时缓解的可能性增加。这一发现提供了重要信息，并强调了在跨诊断治疗计划中针对这些核心症状的重要性。所有患者入院时核心 ED 症状降低，AN 患者入院期间 BMI 升高，以及所有患者住院治疗期间核心 ED 症状减少，表明随访时缓解的可能性增加。这一发现提供了重要信息，并强调了在跨诊断治疗计划中针对这些核心症状的重要性。所有患者入院时核心 ED 症状降低，AN 患者入院期间 BMI 升高，以及所有患者住院治疗期间核心 ED 症状减少，表明随访时缓解的可能性增加。这一发现提供了重要信息，并强调了在跨诊断治疗计划中针对这些核心症状的重要性。