Erythronium japonicum ( E. japonicum ) and Corylopsis coreana Uyeki ( C. coreana Uyeki, Korean winter hazel) have been shown to significantly decrease 1,3-dichloro-2-propanol (1,3-DCP)-induced generation of reactive oxygen species and CYP2E1 activity in HuH7, human hepatocytes. In this study, we expanded upon the previous study and investigated the effects of E. japonicum and C. coreana Uyeki extracts on 1,3-DCP-induced liver damage in rats. The pre-treatment of rats with these extracts alleviated a decrease in body weight and reduced 1,3-DCP-induced increase in catalytic activities of hepatic enzymes, such as aspartate aminotransferase and alanine aminotransferase, in the serum. Moreover, treatment with the extracts restored the 1,3-DCP-induced decreases in anti-oxidant enzyme activities, such as the activities of superoxide dismutase and catalase, in the rat liver. Histopathological studies also strongly supported the results of enzyme activities. These results suggest a possibility that the extracts of E. japonicum and C. coreana Uyeki can be a remedy for alleviating 1,3-DCP-induced liver damage in animals.

中文翻译：

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Erythronium japonicum 和 Corylopsis coreana Uyeki 提取物对 1,3-二氯-2-丙醇诱导的大鼠肝毒性的保护作用

Erythronium japonicum ( E. japonicum ) 和 Corylopsis coreana Uyeki ( C. coreana Uyeki, 韩国冬季榛) 已被证明可以显着减少 1,3-二氯-2-丙醇 (1,3-DCP) 诱导的活性氧的产生HuH7，人肝细胞中的 CYP2E1 活性。在本研究中，我们扩展了之前的研究，并研究了 E. japonicum 和 C. coreana Uyeki 提取物对 1,3-DCP 诱导的大鼠肝损伤的影响。用这些提取物对大鼠进行预处理减轻了体重的下降，并减少了 1,3-DCP 诱导的血清中肝酶（如天冬氨酸氨基转移酶和丙氨酸氨基转移酶）催化活性的增加。此外，用提取物处理恢复了 1,3-DCP 诱导的抗氧化酶活性降低，如大鼠肝脏中超氧化物歧化酶和过氧化氢酶的活性。组织病理学研究也强烈支持酶活性的结果。这些结果表明 E. japonicum 和 C. coreana Uyeki 的提取物可能是减轻 1,3-DCP 引起的动物肝损伤的一种药物。