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The acute impact of resistance training on fatigue in patients with pulmonary sarcoidosis
Chronic Respiratory Disease ( IF 3.5 ) Pub Date : 2020-12-02 , DOI: 10.1177/1479973120967024
Anita Grongstad 1, 2 , Nina Køpke Vøllestad 2 , Line Merethe Oldervoll 3, 4 , Martijn Arthur Spruit 5, 6, 7 , Anne Edvardsen 1
Affiliation  

Fatigue is the most prevalent symptom among patients with sarcoidosis, and skeletal muscle dysfunction is a common clinical feature, making resistance training (RT) a recommended treatment strategy. Despite lacking knowledge regarding whether high-intensity RT will aggravate fatigue, low to moderate-intensity is routinely used even if the evidence for this protocol to improve muscle strength is inconclusive. This study aimed to investigate whether one single session of high-intensity RT induces a higher increase in fatigue than one single session of moderate-intensity RT. In this randomized crossover study, 41 patients with pulmonary sarcoidosis (age: 53 ± 11 yr) were recruited. They randomly performed one single session of high-intensity RT, 4 sets × 5 repetitions maximum (5RM), and one single session of moderate-intensity RT, 2 sets × 25 RM. Fatigue was assessed with the Visual Analogue Scale (0–100 mm) immediately before (T0), immediately after (T1) and 24 hours after (T2) each exercise session. Fatigue development from T0 to T1 was significantly lower after 5RM (−3 ± 18 mm) than after 25RM (5 ± 15 mm), p = 0.004. No difference was seen from T0 to T2 between 5RM (0 ± 17 mm) and 25RM (6 ± 18 mm), p = 0.147. The high-intensity 5RM session did not induce a larger increase in fatigue than the moderate-intensity 25RM session. RT appears feasible and safe in patients with pulmonary sarcoidosis irrespective of the intensity. Thus, the long-term effects of high-intensity RT on fatigue should be explored in a RT programme of longer duration.



中文翻译:

抗阻训练对肺结节病患者疲劳的急性影响

疲劳是结节病患者最普遍的症状,骨骼肌功能障碍是常见的临床特征,因此抗阻训练 (RT) 是推荐的治疗策略。尽管缺乏关于高强度 RT 是否会加重疲劳的知识,但即使该协议提高肌肉力量的证据尚无定论,也常规使用低到中等强度。本研究旨在调查单次高强度 RT 是否比单次中等强度 RT 引起的疲劳增加更多。在这项随机交叉研究中,招募了 41 名肺结节病患者(年龄:53 ± 11 岁)。他们随机进行 1 次高强度 RT,4 组 × 5 次最大重复(5RM),和 1 次中等强度 RT,2 组 × 25 RM。在每次锻炼之前(T0)、之后立即(T1)和之后(T2)使用视觉模拟量表(0-100 mm)评估疲劳。5RM (-3 ± 18 mm) 后从 T0 到 T1 的疲劳发展显着低于 25RM (5 ± 15 mm),p = 0.004。从 T0 到 T2,5RM (0 ± 17 mm) 和 25RM (6 ± 18 mm) 之间没有差异,p = 0.147。与中等强度的 25RM 训练相比,高强度 5RM 训练不会引起更大的疲劳增加。无论强度如何,对于肺结节病患者,放疗似乎都是可行和安全的。因此,高强度 RT 对疲劳的长期影响应在持续时间较长的 RT 计划中进行探索。5RM (-3 ± 18 mm) 后从 T0 到 T1 的疲劳发展显着低于 25RM (5 ± 15 mm),p = 0.004。从 T0 到 T2,5RM (0 ± 17 mm) 和 25RM (6 ± 18 mm) 之间没有差异,p = 0.147。与中等强度的 25RM 训练相比,高强度 5RM 训练不会引起更大的疲劳增加。无论强度如何,对于肺结节病患者,放疗似乎都是可行和安全的。因此,高强度 RT 对疲劳的长期影响应在持续时间较长的 RT 计划中进行探索。5RM (-3 ± 18 mm) 后从 T0 到 T1 的疲劳发展显着低于 25RM (5 ± 15 mm),p = 0.004。从 T0 到 T2,5RM (0 ± 17 mm) 和 25RM (6 ± 18 mm) 之间没有差异,p = 0.147。与中等强度的 25RM 训练相比,高强度 5RM 训练不会引起更大的疲劳增加。无论强度如何,对于肺结节病患者,放疗似乎都是可行和安全的。因此,高强度 RT 对疲劳的长期影响应在持续时间较长的 RT 计划中进行探索。与中等强度的 25RM 训练相比,高强度 5RM 训练不会引起更大的疲劳增加。无论强度如何,对于肺结节病患者,放疗似乎都是可行和安全的。因此,高强度 RT 对疲劳的长期影响应在持续时间较长的 RT 计划中进行探索。与中等强度的 25RM 训练相比,高强度 5RM 训练不会引起更大的疲劳增加。无论强度如何,对于肺结节病患者,放疗似乎都是可行和安全的。因此,高强度 RT 对疲劳的长期影响应在持续时间较长的 RT 计划中进行探索。

更新日期:2020-12-02
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