Atherosclerosis (AS) is a chronic inflammatory disease accompanied by complex pathological changes, such as endothelial dysfunction, foam cell formation, and vascular smooth muscle cell proliferation. Many approaches, including regulating AS-related gene expression in the transcriptional or post-transcriptional level, contribute to alleviating AS development. The DNA methylation is a crucial epigenetic modification in regulating cell function by silencing the relative gene expression. The microRNA (miRNA) is a type of noncoding RNA that plays an important role in gene post-transcriptional regulation and disease development. The DNA methylation and the miRNA are important epigenetic factors in AS. However, recent studies have found a mutual regulation between these two factors in AS development. In this study, recent insights into the roles of miRNA and DNA methylation and their interaction in the AS progression are reviewed.

中文翻译：

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动脉粥样硬化中microRNA和DNA甲基化之间的相互作用

动脉粥样硬化（AS）是一种慢性炎性疾病，伴有复杂的病理变化，例如内皮功能障碍，泡沫细胞形成和血管平滑肌细胞增殖。许多方法，包括在转录或转录后水平上调节与AS有关的基因表达，都有助于减轻AS的发展。DNA甲基化是通过沉默相关基因表达来调节细胞功能的重要表观遗传修饰。microRNA（miRNA）是一种非编码RNA，在基因转录后调控和疾病发展中起着重要作用。DNA甲基化和miRNA是AS中重要的表观遗传因子。但是，最近的研究发现AS发展中这两个因素之间存在相互调节的关系。在这个研究中，