Abstract

In this research work, was utilized green process for the synthesis of chromen derivatives is illustrated using one-pot reactions of anthranilic acid, 2-hydroxyacetophenone or its derivatives and dimethyl carbonate in the vicinity of catalytic amount of KF/Clinoptilolite nanoparticles in water as green solvent at 80 °C in short time. This procedure that is described here have some advantages such as short time of reaction, simple and green procedure, using low-cost catalyst, generation of product with excellent yield and employing various substrate for doing these reactions.

• Highlights

• Among heterocyclic compounds, chromene derivatives are important compounds with biological property for instance anticancer, anti-inflammatory, antimicrobial, antihyperglycemic and antineurodegenerative disorders similar to Alzheimer’s, Parkinson illness.

• The present methodology avoids the use of toxic catalyst.

• Also, chromenes are one of the imperative heterocyclic compounds that are seen broadly in plant, microorganisms and animals.

• This recoverable catalyst makes this protocol attractive and useful as an eco-safe catalyst with high yields of products.

摘要

在这项研究工作中，利用绿色工艺合成色烯衍生物，以邻氨基苯甲酸、2-羟基苯乙酮或其衍生物与碳酸二甲酯在催化量附近的 KF/斜发沸石纳米颗粒在水中的一锅反应为例进行说明。在 80°C 的短时间内溶解。这里描述的这个过程具有一些优点，例如反应时间短、过程简单和绿色、使用低成本的催化剂、产生具有优异收率的产物以及使用各种底物进行这些反应。

• 强调

• 在杂环化合物中，色烯衍生物是具有生物学特性的重要化合物，例如与阿尔茨海默病、帕金森病类似的抗癌、抗炎、抗微生物、抗高血糖和抗神经退行性疾病。

• 本方法避免使用有毒催化剂。

• 此外，色烯是广泛存在于植物、微生物和动物中的必需杂环化合物之一。

• 这种可回收的催化剂使该协议作为具有高产率的生态安全催化剂具有吸引力和有用性。