ABSTRACT

Introduction: Traumatic bone infection represents a clinical challenge for orthopedic surgeons. Traditional treatments include surgical debridement and antibiotic, but prolonged use of antibiotic may lead to colonization of resistant bacteria and other adverse reactions.

Areas covered: Platelet-rich plasma (PRP), a biological product extracted from the peripheral blood of patients, has been widely used in the field of tissue repair in recent years. Because if its structural and antibacterial properties, PRP is an innovative option for the prevention and treatment of infections. This review assesses the recent scientific literature on PRP, specifically its in the treatment of infections. To this end, a literature review was conducted using the PubMed and Web of Science databases with the following keywords ‘platelet-rich plasma (PRP)’; ‘PRP AND traumatic bone infections’; ‘PRP AND bone defect’; ‘PRP AND antibiotics’; and ‘PRP AND wound healing’.

Expert opinion: This review focuses on the mechanism of action, preparation methods, clinical applications and other aspects related to PRP to provide a reference for its use in the treatment of traumatic bone infections, thereby enhancing the therapeutic effectiveness and improving the prognosis of patients.

摘要

简介：外伤性骨感染是骨科医生面临的临床挑战。传统治疗方法包括手术清创和抗生素，但长期使用抗生素可能导致耐药菌定植和其他不良反应。

涵盖领域： 富血小板血浆（PRP）是一种从患者外周血中提取的生物制品，近年来广泛应用于组织修复领域。因为如果其结构和抗菌特性，PRP 是预防和治疗感染的创新选择。这篇综述评估了最近关于 PRP 的科学文献，特别是它在感染治疗方面的研究。为此，使用 PubMed 和 Web of Science 数据库进行了文献综述，关键词为“富含血小板的血浆 (PRP)”；“PRP 和创伤性骨感染”；'PRP 和骨缺损'; “PRP 和抗生素”；和“PRP 和伤口愈合”。

专家意见：本综述重点从PRP的作用机制、制备方法、临床应用等方面进行综述，为其在创伤性骨感染治疗中的应用提供参考，从而提高治疗效果，改善患者预后。