Hepatitis C virus (HCV) infection has detrimental effects on patient and graft survival after kidney transplantation. In the pre‐direct‐acting antiviral (DAA) era, treatment of HCV infection was associated with low response rates, poor tolerance, and increased risk of allograft rejection. However, DAAs have revolutionized HCV treatment. The aims of this study were to determine the impact of DAA on the sustained virologic response (SVR), renal function, and calcineurin inhibitor (CNI) levels and assess the tolerability to treatment in kidney transplant recipients with HCV infection in Qatar.

中文翻译：

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使用直接抗病毒疗法根除肾移植受者丙型肝炎病毒感染：卡塔尔经验

丙型肝炎病毒 (HCV) 感染对肾移植后患者和移植物的存活有不利影响。在前直接作用抗病毒 (DAA) 时代，HCV 感染的治疗与低反应率、低耐受性和同种异体移植排斥风险增加有关。然而，DAAs 已经彻底改变了 HCV 治疗。本研究的目的是确定 DAA 对持续病毒学应答 (SVR)、肾功能和钙调神经磷酸酶抑制剂 (CNI) 水平的影响，并评估卡塔尔感染 HCV 的肾移植受者对治疗的耐受性。