A metal‐free visible light promoted three‐component facile synthesis of 4‐oxo‐tetrahydroindoles in ethanol–water,Journal of Heterocyclic Chemistry

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A metal‐free visible light promoted three‐component facile synthesis of 4‐oxo‐tetrahydroindoles in ethanol–water
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-12-01 , DOI: 10.1002/jhet.4202
Khursheed Ansari ₁ , Mohd Nazeef ₁ , Shabir Ali ₂ , Malik A. Waseem ₃ , Wajaht A. Shah ₃ , Saif Ansari ₁ , Ibadur R. Siddiqui ₁ , Jagdamba Singh ₄

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A mild and efficient visible light–mediated one‐pot multicomponent tandem approach to construct 4‐oxo‐tetrahydroindoles in ethanol–water medium at room temperature has been described. The characteristics of reported methodology are the utilization of visible light, an ideal source of energy to generate CC and CN bonds from commercially available substrates namely dimedone, phenacyl bromides, and amines. The presented protocol is highly compatible for developing 4‐oxo‐tetrahydroindole derivatives with improved selectivity and high yields. Moreover, metal‐free synthesis, environmental friendly solvent, easy workup process, high atom economy, cost‐effectiveness, short reaction time, and broad substratescope are the major advantages of reported protocol.

中文翻译：

无金属的可见光促进了乙醇-水中三氧四氢吲哚的三组分合成

已经描述了一种温和有效的可见光介导的单锅多组分串联方法，可在室温下在乙醇-水介质中构建4-氧代-四氢吲哚。所报告方法的特点是利用可见光，这是一种理想的能源，可以从可商购获得的底物，即二甲酮，苯甲酰溴和胺中生成C andC和CN键。所提出的方案与开发4-氧-四氢吲哚衍生物具有高度的兼容性，具有更高的选择性和高收率。此外，无金属合成，环境友好的溶剂，简便的后处理，高原子经济性，成本效益，反应时间短和广泛的底物范围是所报道方案的主要优点。

更新日期：2020-12-01

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