Bulk Modification of Thermoplastic Polyurethanes for Self‐Sterilization of Trachea Intubation,Macromolecular Bioscience

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Bulk Modification of Thermoplastic Polyurethanes for Self‐Sterilization of Trachea Intubation
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-12-02 , DOI: 10.1002/mabi.202000318
Yifan Guo ₁ , Hongfa Zhang ₁ , Shun Duan ₁ , Xiaokang Ding ₁ , Yang Hu ₁ , Xuejia Ding ₁ , Fu-Jian Xu ₁

Affiliation

Implantable medical devices are widely used, but biomaterial‐associated infections (BAIs) impose a huge economic burden and increase the mortality of patients. Therefore, BAIs are a serious concern that must be urgently resolved. Materials with antibacterial properties have become hotspots of current research and development. In the present work, quaternized chitosan (QCS) is used as an antibacterial agent and blended with thermoplastic polyurethane (TPU) to create an antibacterial material for tracheal intubation tubes. The modified TPU material (QCS‐TPU) exhibited good mechanical properties and excellent long‐term antibacterial performance. Under in vitro hydrodynamic conditions, QCS‐TPU retained its strong antibacterial properties. QCS‐TPU also possessed a low hemolysis rate and cytotoxicity. The current work is expected to provide a facile and feasible strategy for the preparation of antibacterial catheters and aid in the discovery of promising clinical applications to prevent BAIs.

中文翻译：

用于气管插管自灭菌的热塑性聚氨酯的本体改性

植入式医疗设备被广泛使用，但生物材料相关感染（BAI）带来了巨大的经济负担并增加了患者的死亡率。因此，BAI 是一个必须紧急解决的严重问题。具有抗菌性能的材料已成为当前研究开发的热点。在目前的工作中，季铵化壳聚糖（QCS）被用作抗菌剂，并与热塑性聚氨酯（TPU）共混，制造出用于气管插管的抗菌材料。改性TPU材料（QCS-TPU）表现出良好的机械性能和优异的长期抗菌性能。在体外流体动力学条件下，QCS-TPU 保留了其强大的抗菌性能。 QCS-TPU还具有低溶血率和细胞毒性。目前的工作有望为抗菌导管的制备提供一种简便可行的策略，并有助于发现预防 BAI 的有前景的临床应用。

更新日期：2020-12-02

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