A series of benzo[a]chromeno[2,3‐c]phenazine derivatives were synthesized through an efficient one‐pot, multicomponent eco‐friendly reaction of 2‐hydroxynaphthalene‐1,4‐dione, o‐phenylenediamines, cyclic 1,3‐dicarbonyl compounds and aromatic aldehydes, promoted by glycerol. To the best of our knowledge this is the first catalyst free protocol for synthesis of this important scaffold having potential applications in medicinal and materials chemistry. Other important attributes of the present method are the use of glycerol as a bio‐renewable and biodegradable reaction medium‐cum‐promoter, use of readily available substrates, mild reaction conditions, operational simplicity, broad substrate scope, short reaction time, easy workup, and high yields and atom efficiency, which makes the disclosed protocol a superior alternative to existing methods.

中文翻译：

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甘油作为可循环利用和可生物降解的促进介质，使用无催化剂的多组分绿色方法制备苯并[a]色诺[2,3-c]吩嗪

一系列苯并[一个]色烯并[2,3- c ^ ]吩嗪衍生物是通过一种有效的单罐合成，2-羟基萘-1,4-二酮的多组分生态友好的反应，ö甘油促进的苯二胺，环状1，3-二羰基化合物和芳香醛。据我们所知，这是用于合成这种重要骨架的第一个无催化剂方案，在药物和材料化学中具有潜在的应用。本方法的其他重要属性是使用甘油作为生物可再生和可生物降解的反应介质兼促进剂，使用现成的底物，温和的反应条件，操作简便，底物范围广，反应时间短，易于后处理，以及高产率和原子效率，这使得所公开的方案成为现有方法的替代方案。