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Critical roles of the lncRNA CASC11 in tumor progression and cancer metastasis: The biomarker and therapeutic target potential
Genes & Diseases ( IF 6.9 ) Pub Date : 2020-12-02 , DOI: 10.1016/j.gendis.2020.11.016
Bei Wang 1 , Wen Xu 1 , Chengyu Hu 1 , Kai Liu 1 , Jinlan Chen 1 , Chong Guo 1 , Chengfu Yuan 1, 2, 3
Affiliation  

The frequency of human suffering from cancer is increasing annually across the globe. This has fueled numerous investigations aimed at the prevention and cure of various cancers. Long non-coding RNA (lncRNA) are known to play a crucial role in cancer. For instance, cancer susceptibility candidate 11 (CASC11), as one of the long non-coding RNAs, has been reported to be overexpressed in various tumors. This review elucidates the mechanism by which lncRNA CASC11 regulates tumors' biological processes and affirms its value as a therapeutic target for tumors. Through systematic analysis and review of relevant articles in PubMed, we revealed the pathophysiological mechanism of CASC11 on the tumor by regulating the biological processes of tumor such as proliferation, autophagy, apoptosis, thereby promoting tumor metastasis. We also revealed the regulatory pathways of CASC11 in different tumors, for instance by acting on a variety of microRNAs, oncogenic proteins, carcinogens, and transcription factors. Consequently, CASC11 regulates cancer proliferation, apoptosis, and invasion by altering the WNT/β-catenin signaling pathway and epithelial–mesenchymal transition (EMT). Furthermore, CASC11 expression has a high pertinence with clinical prognosis, suggesting that it is a potential marker for malignant tumors or a clinical adjuvant therapy in the future.



中文翻译:

lncRNA CASC11在肿瘤进展和癌症转移中的关键作用:生物标志物和治疗靶点潜力

在全球范围内,人类患癌症的频率每年都在增加。这推动了许多旨在预防和治疗各种癌症的研究。众所周知,长链非编码 RNA (lncRNA) 在癌症中起着至关重要的作用。例如,据报道,癌症易感性候选物 11 (CASC11) 作为一种长链非编码 RNA,在各种肿瘤中过表达。本综述阐明了lncRNA CASC11调节肿瘤生物学过程的机制,并肯定了其作为肿瘤治疗靶点的价值。通过对PubMed相关文章的系统分析和回顾,我们揭示了CASC11通过调节肿瘤的增殖、自噬、凋亡等生物学过程,从而促进肿瘤转移的病理生理机制。我们还揭示了 CASC11 在不同肿瘤中的调节途径,例如通过作用于各种 microRNA、致癌蛋白、致癌物和转录因子。因此,CASC11 通过改变 WNT/β-catenin 信号通路和上皮-间质转化 (EMT) 来调节癌症的增殖、凋亡和侵袭。此外,CASC11的表达与临床预后具有高度的相关性,提示其为恶性肿瘤的潜在标志物或未来的临床辅助治疗。通过改变 WNT/β-catenin 信号通路和上皮-间质转化 (EMT) 进行侵袭。此外,CASC11的表达与临床预后具有高度的相关性,提示其为恶性肿瘤的潜在标志物或未来的临床辅助治疗。通过改变 WNT/β-catenin 信号通路和上皮-间质转化 (EMT) 进行侵袭。此外,CASC11的表达与临床预后具有高度的相关性,提示其为恶性肿瘤的潜在标志物或未来的临床辅助治疗。

更新日期:2020-12-02
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