Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder with chronic hyperglycemia. Genome-wide association studies (GWAS) have identified many genes and, among them, solute carrier family 30 member 8 (SLC30A8) was one of the important genes linked to the development of T2DM risk. The relationship between T2DM and the SLC30A8 gene is linked through zinc, which plays a key role in the storage and secretion of insulin. The rs13266634 polymorphism includes a strong genetic association in case-control and meta-analysis studies of the global population. The aim of this current study was to scrutinize the genetic relationship between the rs13266634 polymorphism in the SLC30A8 gene with T2DM subjects selected with a family history in the Saudi population. This study involved 120 cases of diagnosed T2DM and 120 confirmed healthy controls that were recruited to screen rs13266634 polymorphisms through a genotyping analysis followed by PCR and RFLP analysis. Baseline characteristics between cases and controls have been evaluated with Student’s t-test. The study results confirmed the genetic association between the allele (p = 0.001), genotypes (CT = 0.005 and TT = 0.03), and various genetic patterns of inheritance (p = 0.001 and p = 0.02). Both analysis of variance (ANOVA) and binary logistic regression analysis revealed non-signiifcant association with T2DM cases and biochemical parameters (p > 0.05). In conclusion, the current results have confirmed the strong genetic association between T2DM cases and controls in the Saudi population with rs13266634 polymorphisms of the SLC30A8 gene.

2型糖尿病（T2DM）是一种复杂的代谢紊乱，伴有慢性高血糖症。全基因组关联研究（GWAS）已鉴定出许多基因，其中溶质载体家族30成员8（SLC30A8）是与T2DM风险发展相关的重要基因之一。T2DM与SLC30A8基因之间的关系通过锌连接，锌在胰岛素的储存和分泌中起关键作用。rs13266634多态性在全球人群的病例对照和荟萃分析研究中包括强大的遗传关联。本研究的目的是研究SLC30A8中rs13266634多态性之间的遗传关系该基因与沙特人群中有家族史的T2DM受试者有关。这项研究涉及120例经诊断的T2DM病例和120例经确认的健康对照，通过基因分型分析，PCR和RFLP分析，招募筛选rs13266634多态性的患者。病例和对照之间的基线特征已经用学生的t-测试。研究结果证实了等位基因（p = 0.001），基因型（CT = 0.005和TT = 0.03）和各种遗传模式（p = 0.001和p = 0.02）之间的遗传关联。方差分析（ANOVA）和二元logistic回归分析均显示与T2DM病例和生化参数无显着相关性（p> 0.05）。总之，目前的结果证实了沙特人群中T2DM病例与对照之间存在强的遗传联系，且SLC30A8基因具有rs13266634多态性。