It is reported that approximately 40 million people are suffering from dementia, globally. Dementia is a group of symptoms that affect neurons and cause some mental disorders, such as losing memory. Alzheimer's disease (AD) which is known as the most common cause of dementia, is one of the top medical care concerns across the world. Although the exact sources of the disease are not understood, is it believed that aggregation of amyloid-beta (Aβ) outside of neuron cells and tau aggregation or neurofibrillary tangles (NFTs) formation inside the cell may play crucial roles. In this paper, we are going to review studies that targeted inhibition of amyloid plaque and tau protein tangle formation, to suppress or postpone AD.

据报道，全球约有四千万人患有痴呆症。痴呆症是一组影响神经元并引起某些精神障碍（例如记忆力减退）的症状。阿尔茨海默氏病（AD）被认为是痴呆症的最常见病因，是世界上最关注的医疗保健问题之一。尽管尚不清楚该疾病的确切来源，但据信神经元细胞外的淀粉样β（Aβ）聚集以及细胞内tau聚集或神经原纤维缠结（NFT）的形成可能起关键作用。在本文中，我们将回顾针对抑制淀粉样斑块和tau蛋白缠结形成以抑制或推迟AD的研究。