Cell culture processes are used to produce the vast majority of protein therapeutics, valued at over US$180 billion per annum worldwide. For more than a decade now, these processes have become highly productive. To further enhance capital efficiency, there has been an increase in the adoption of disposable apparatus and continuous processing, as well as a greater exploration of in-line sensing, various -omic tools, and cell engineering to enhance process controllability and product quality consistency. These feats in cell culture processing for protein biologics will help accelerate the bioprocess advancements for virus and cell therapy applications.

中文翻译：

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细胞培养生物加工——所采取的道路和前进的道路

细胞培养过程用于生产绝大多数蛋白质治疗药物，全球每年价值超过 1800 亿美元。十多年来，这些流程已经变得非常高效。为了进一步提高资本效率，一次性设备和连续处理的采用有所增加，并对在线传感、各种组学工具和细胞工程进行了更大的探索，以增强过程的可控性和产品质量的一致性。蛋白质生物制品细胞培养加工方面的这些壮举将有助于加速病毒和细胞治疗应用的生物工艺进步。