Actinoplanes sp. A1094 strain had been selected for its high production of acarbose from 20 different strains of Actinoplanes sp. can be found in wild. The content for glucosidase inhibitor of acarbose concentration was recorded at 1.12 g/L. The conducted analysis of 16S rRNA sequence of Actinoplanes sp. A1094 showed 99% similar identity to the corresponding sequence of Actinoplanes hulinensis. Acarbose was purified from Actinoplanes hulinensis 1094 with a yield of 8.48%, purity of 98% and further identified by LC/MS and NMR methods (C₂₅H₄₃NO₁₈; m/z: 645.6 g/mol). The purified acarbose was used to evaluate the hypoglycemia in streptozotocin (STZ)-induced diabetic mice model. The purified acarbose reduced postprandial blood glucose level in comparison with Glucobay® as medication for control type 2 diabetes in a combination therapy. Notably, the outcomes of native acarbose on fasting blood glucose levels in mice resemble much akin to the commercial product and the acarbose accumulating fermentation and metabolic engineering from the cell gene in which would reduce in production cost. Therefore, acarbose from Actinoplanes hulinensis 1094 could be potentially used to make products for the treatment of type II diabetes.

放线飞机sp。已从20种不同的Actinoplanes sp。菌株中选择了A1094菌株以产生高水平的阿卡波糖。可以在野外找到。阿卡波糖浓度的葡糖苷酶抑制剂的含量记录为1.12g / L。对Actinoplanes sp。的16S rRNA序列进行了分析。A1094显示出与虎草放线放线菌的相应序列99％的相似性。从Actinoplanes hulinensis 1094中纯化出阿卡波糖，收率为8.48％，纯度为98％，并通过LC / MS和NMR方法进一步鉴定（C ₂₅ H ₄₃ NO ₁₈; m / z：645.6 g / mol）。纯化的阿卡波糖用于评估链脲佐菌素（STZ）诱导的糖尿病小鼠模型中的低血糖。与作为联合治疗中2型糖尿病对照药物的Glucobay®相比，纯化的阿卡波糖降低了餐后血糖水平。值得注意的是，天然阿卡波糖对小鼠空腹血糖水平的影响与商业产品非常相似，并且阿卡波糖通过细胞基因积累发酵和代谢工程，从而降低了生产成本。因此，来自Actinoplanes hulinensis 1094的阿卡波糖可潜在地用于制造用于治疗II型糖尿病的产品。