Biofuels and bio-based chemicals are getting more and more attention because of their sustainable and renewable properties and wide industrial applications. However, the low concentrations of the targeted products in their fermentation broths, the complicated components of the broths and the high energy-intensive separation and purification process hinder the competitiveness of biofuels and biochemicals with the petro-based ones. Hence, the production and the separation of biofuels and bio-based chemicals in energy-saving, low-cost and greenness ways become hot topics nowadays. This review introduces the separation technologies (salting-out extraction, salting-out, sugaring-out extraction, and sugaring-out) that extract biobutanol, 1,3-propanediol, 2,3-butanediol, acetoin, organic acids and other bio-based chemicals from fermentation broths/aqueous solutions. Salting-out/sugaring-out extraction and salting-out/sugaring-out technologies display the high separating efficiency and the high targeted product yields. In addition, they are easy to operate and require low cost for separating products. Hence, they are the effective and potential technologies for separating targeted products in the wide industrial applications. The successful research into the salting-out/ sugaring-out and salting-out/sugaring-out extraction not only affords biofuels and biochemical but also opens a door for the development of novel separation methods.

生物燃料和基于生物的化学品由于其可持续和可再生的特性以及广泛的工业应用而受到越来越多的关注。但是，目标产物在发酵液中的浓度低，发酵液的成分复杂以及高能耗的分离和提纯过程阻碍了生物燃料和生化产品与石油基产品竞争。因此，以节能，低成本和绿色方式生产和分离生物燃料和生物基化学物质成为当今的热门话题。这篇综述介绍了分离技术（盐析萃取，盐析，糖析萃取和糖析），它们提取了生物丁醇，1,3-丙二醇，2,3-丁二醇，乙酰丁香，发酵液/水溶液中的有机酸和其他生物基化学品。盐析/糖化提取和盐析/糖化技术显示出高分离效率和高目标产物产率。另外，它们易于操作并且分离产品所需的成本较低。因此，它们是在广泛的工业应用中分离目标产品的有效和潜在技术。盐析/糖析和盐析/糖析提取的成功研究不仅提供了生物燃料和生化物质，而且为开发新的分离方法打开了一扇门。它们易于操作，并且分离产品的成本较低。因此，它们是在广泛的工业应用中分离目标产品的有效和潜在技术。盐析/糖析和盐析/糖析提取的成功研究不仅提供了生物燃料和生化物质，而且为开发新的分离方法打开了一扇门。它们易于操作，并且分离产品的成本较低。因此，它们是在广泛的工业应用中分离目标产品的有效和潜在技术。盐析/糖析和盐析/糖析提取的成功研究不仅提供了生物燃料和生化物质，而且为开发新的分离方法打开了一扇门。