We studied the effects of simulated microgravity (10 days) on the production of extracellular matrix proteins and expression of extracellular matrix-associated genes in human mesenchymal stem cells. A decrease in collagen production, reduced expression of TIMP-1, TIMP-3, and MMP-11 genes, and enhanced expression of tenascin and laminin subunit were revealed. The results attest to activation of proteolytic processes in the matrix of mesenchymal stromal cells and weakening of cell adhesion to extracellular matrix under conditions of simulated microgravity.

中文翻译：

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微重力效应建模过程中细胞外基质蛋白和间充质基质细胞基质相关基因的转录

我们研究了模拟微重力（10 天）对人间充质干细胞中细胞外基质蛋白的产生和细胞外基质相关基因表达的影响。揭示了胶原蛋白生成减少、TIMP-1、TIMP-3 和 MMP-11 基因表达减少以及生腱蛋白和层粘连蛋白亚基表达增强。结果证明，在模拟微重力条件下，间充质基质细胞基质中的蛋白水解过程被激活，细胞与细胞外基质的粘附减弱。