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Estimation of Absolute Bioavailability of the Chemical Substance of the Anti-Smallpox Preparation NIOCH-14 in Mice
Bulletin of Experimental Biology and Medicine ( IF 0.7 ) Pub Date : 2020-12-01 , DOI: 10.1007/s10517-020-05034-x O Yu Mazurkov 1 , L N Shishkina 1 , N I Bormotov 1 , M O Skarnovich 1 , O A Serova 1 , N A Mazurkova 1 , A A Chernonosov 2 , A Ya Tikhonov 3 , B A Selivanov 3
Bulletin of Experimental Biology and Medicine ( IF 0.7 ) Pub Date : 2020-12-01 , DOI: 10.1007/s10517-020-05034-x O Yu Mazurkov 1 , L N Shishkina 1 , N I Bormotov 1 , M O Skarnovich 1 , O A Serova 1 , N A Mazurkova 1 , A A Chernonosov 2 , A Ya Tikhonov 3 , B A Selivanov 3
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We compared absolute bioavailability of the chemical substance of the anti-smallpox preparation NIOCH-14 and chemical compound ST-246 active against orthopoxviruses after oral administration to mice in doses of 10 and 50 μg/g and intravenous administration to mice in a dose of 2 μg/g body weight. The absolute bioavailability of NIOCH-14 is comparable with the absolute bioavailability of ST-246.
中文翻译：
小鼠抗天花制剂 NIOCH-14 化学物质绝对生物利用度的估计
我们比较了抗天花制剂 NIOCH-14 的化学物质和化合物 ST-246 在以 10 和 50 μg/g 的剂量对小鼠口服给药和以 2微克/克体重。NIOCH-14 的绝对生物利用度与 ST-246 的绝对生物利用度相当。
更新日期：2020-12-01
中文翻译：
小鼠抗天花制剂 NIOCH-14 化学物质绝对生物利用度的估计
我们比较了抗天花制剂 NIOCH-14 的化学物质和化合物 ST-246 在以 10 和 50 μg/g 的剂量对小鼠口服给药和以 2微克/克体重。NIOCH-14 的绝对生物利用度与 ST-246 的绝对生物利用度相当。
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