We analyzed association of rs4680 polymorphism of catechol-O-methyltransferase (COMT) gene with clinical parameters of the tumor in patients with colorectal cancer (n=100). Based on the classification of the tumor according to the TNM system, groups were formed taking into account the size and spreading of the primary tumor (T1+T2 vs Т3+Т4) and the presence of regional (N0 vs N1) and distant metastases (M0 vs M1). An association of the AA genotype with an almost 7-fold increased capacity for invasive tumor growth was found (p<0.05; according to recessive (AA vs GG+GA) and codominant (AA vs GG) inheritance models). A positive relationship of minor allele A with increased malignancy of tumor cells was revealed at the trend level. No significant associations with either regional or distant metastasis were found.

中文翻译：

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rs4680 COMT 多态性与结直肠癌肿瘤临床参数相关性的评估（初步研究）

我们分析了儿茶酚-O-甲基转移酶 (COMT) 基因的 rs4680 多态性与结直肠癌患者 (n=100) 肿瘤临床参数的关联。根据TNM系统对肿瘤的分类，考虑原发肿瘤的大小和扩散（T1+T2 vs Т3+Т4）以及区域（N0 vs N1）和远处转移的存在（ M0 对 M1）。发现 AA 基因型与侵袭性肿瘤生长能力增加近 7 倍相关（p<0.05；根据隐性（AA vs GG+GA）和共显性（AA vs GG）遗传模型）。在趋势水平上揭示了次要等位基因 A 与肿瘤细胞恶性程度增加的正相关关系。未发现与区域或远处转移的显着关联。