Alimentary atherosclerosis is associated with a significant decrease in the content of phosphatidylcholine, the phospholipid that provides antioxidant protection, in the plasma membrane of liver cells, while the level of phosphatidic acid that initiates generation of superoxides, on the contrary, increases. The level of membrane phosphatidylserine, a target of the scavenger receptors, which initiates removal of damaged cells and modified lipoproteins from the circulation was also elevated. In the blood serum of rabbits receiving an atherogenic diet, the content of cardiolipin involved in the immune mechanisms of atherosclerosis development and a risk factor for thrombosis, sharply increased. The level of lysophosphatidylcholine that mediates initiation and progression of atherosclerosis increased. The content of phosphatidylinositol that is involved in the mechanisms protecting from exposure to excess cholesterol was significantly reduced. Treatment of alimentary atherosclerosis with "empty" phosphatidylcholine nanosomes eliminates the key factors initiating atherosclerosis development.

中文翻译：

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磷脂酰胆碱纳米体对实验性动脉粥样硬化肝细胞质膜和血清磷脂成分的影响

消化道动脉粥样硬化与肝细胞质膜中提供抗氧化保护的磷脂酰胆碱含量显着降低有关，而引发超氧化物生成的磷脂酸含量反而增加。膜磷脂酰丝氨酸（清道夫受体的靶标，可启动从循环中清除受损细胞和修饰的脂蛋白）的水平也升高。在接受致动脉粥样硬化饮食的兔子的血清中，参与动脉粥样硬化发展的免疫机制和血栓形成危险因素的心磷脂含量急剧增加。介导动脉粥样硬化发生和进展的溶血磷脂酰胆碱水平增加。参与防止暴露于过量胆固醇的机制的磷脂酰肌醇含量显着降低。用“空”磷脂酰胆碱纳米体治疗消化道动脉粥样硬化消除了引发动脉粥样硬化发展的关键因素。