Some studies suggested an association between Helicobacter pylori infection and iron-deficiency anemia, however, the link between weight loss and the infection in childhood remains non-established. In a retrospective cohort study, we compared H. pylori positivity rates of Bulgarian children without or with anemia (47 children in each group) or weight loss (45 children in each group) and both conditions (17 children in each group). H. pylori infection was associated with the presence of anemia (in 76.6% of the anemic vs. 21.3% of the non-anemic patients, P < 0.0001) and weight loss (in 82.2% of the patients vs. 17.8% of the control children, P < 0.0001). All 17 patients with both conditions were H. pylori positive. Relative risk of anemia, weight loss and both conditions was 3.6 (95% CI, 2.0-6.4), 4.6 (95% CI, 2.4-8.8) and 5.7 (95% CI, 2.0-15.8), respectively, in the children with H. pylori infection. In conclusion, H. pylori infection was significantly associated with iron-deficiency anemia or/and weight loss in Bulgarian pediatric patients. Therefore, diagnostics and treatment of the infection as well as a proper control of the eradication success can be beneficial and thus, can be recommended for children with those conditions.

中文翻译：

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幽门螺杆菌感染与保加利亚儿童的贫血、体重减轻或两者都有关联。

一些研究表明幽门螺杆菌感染与缺铁性贫血之间存在关联，但是，体重减轻与儿童期感染之间的联系仍未确定。在一项回顾性队列研究中，我们比较了没有或有贫血（每组 47 名儿童）或体重减轻（每组 45 名儿童）和两种情况（每组 17 名儿童）的保加利亚儿童的幽门螺杆菌阳性率。H. pylori 感染与贫血（76.6% 的贫血患者 vs. 21.3% 的非贫血患者，P < 0.0001）和体重减轻（82.2% 的患者 vs. 17.8% 的对照组）有关儿童，P < 0.0001）。患有这两种疾病的所有 17 名患者均为 H. pylori 阳性。贫血、体重减轻和这两种情况的相对风险分别为 3.6（95% CI，2.0-6.4）、4.6（95% CI，2.4-8.8）和 5.7（95% CI，2.0-15）。8)，分别在儿童幽门螺杆菌感染中。总之，幽门螺杆菌感染与保加利亚儿童患者的缺铁性贫血或/和体重减轻显着相关。因此，感染的诊断和治疗以及对根除成功的适当控制可能是有益的，因此可以推荐给患有这些疾病的儿童。