Saprochaete clavata is an emerging opportunistic pathogen, that causes life-threatening infections, but there are limited evidence and information about the evaluation of in vitro antifungal susceptibility test results. The aim of this study was to determine S. clavata isolates from clinical specimens and to investigate their in vitro antifungal susceptibility. S. clavata was identified by API ID20C AUX (BioMérieux, Brussels, Belgium), MALDI TOF (Bruker Daltonik, Germany), and ITS gene region sequencing. In vitro susceptibility tests were performed using Sensititre YeastOne (TREK Diagnostic System, East Grinstead, UK). During the study period, 4,736 fungi were isolated from various clinical samples and, S. clavata was identified in eight patients with underlying diseases namely, pancreatic neoplasma, acute myeloid leukaemie, follicular lymphoma, cholelithiasis. Anidulafungin and micafungin minimum inhibitory concentration values were 1-2 and 1-4 mg/L, respectively, while those of the azole group antifungals were much lower. This is the first study in Turkey reporting isolation, identification and antifungal susceptibilities of S. clavata from clinical specimens. Higher MIC values seen in some isolates suggest that continuous monitoring of sensitivity rates and observation of regional differences will thus be useful guides in determining infection control and antifungal use policies.

中文翻译：

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来自土耳其侵入性感染的棒状腐生菌的鉴定和抗真菌敏感性。

Saprochaete clavata 是一种新兴的机会性病原体，会导致危及生命的感染，但关于体外抗真菌药敏试验结果评估的证据和信息有限。本研究的目的是确定从临床标本中分离出的 S. clavata，并研究它们的体外抗真菌敏感性。S. clavata 通过 API ID20C AUX（BioMérieux，Brussels，Belgium）、MALDI TOF（Bruker Daltonik，Germany）和 ITS 基因区域测序进行鉴定。使用 Sensititre YeastOne（TREK Diagnostic System，East Grinstead，UK）进行体外药敏试验。在研究期间，从各种临床样本中分离出 4,736 种真菌，并在 8 名患有基础疾病的患者中发现了 S. clavata，即胰腺肿瘤、急性髓系白血病、滤泡性淋巴瘤、胆石症。阿尼芬净和米卡芬净的最低抑菌浓度值分别为 1-2 和 1-4 mg/L，而唑类抗真菌药的最低抑菌浓度值要低得多。这是土耳其第一项报告从临床标本中分离、鉴定和抗真菌敏感性的 S. clavata 研究。在某些分离株中观察到的较高 MIC 值表明，持续监测敏感率和观察区域差异将因此成为确定感染控制和抗真菌使用政策的有用指南。来自临床标本的克拉瓦塔。在某些分离株中观察到的较高 MIC 值表明，持续监测敏感率和观察区域差异将因此成为确定感染控制和抗真菌使用政策的有用指南。来自临床标本的克拉瓦塔。在某些分离株中观察到的较高 MIC 值表明，持续监测敏感率和观察区域差异将因此成为确定感染控制和抗真菌使用政策的有用指南。