Tuberculosis (TB) and HIV/AIDS are major public health issues globally. The burden of these diseases is particularly significant in Nigeria due to the high TB and HIV/AIDS prevalence. This meta-analysis for the 1st time addressed the TB/HIV coinfection prevalence in Nigeria at the regional level. A total of 58 relevant publications comprising 80 studies (n = 44,508) were obtained from PUBMED, ScienceDirect, African Journals Online, and Cochrane Library databases using carefully constructed keywords combinations. The PRISMA guideline was followed for this meta-analysis. Two independent reviewers conducted the publication screening, data extraction and methodological quality appraisal with a third reviewer serving as arbitrator. The pooled estimates were calculated using the random effects model. Heterogeneity was assessed using Cochran's Q and I 2 statistic. Univariate and multivariate meta-regressions were done to predict sources of between-study heterogeneity. Overall, the pooled prevalence of TB/HIV coinfection was 25.8%. The highest coinfection prevalence of 34.3% was recorded among the North Central States of Nigeria, while the least prevalence of 19.3% was recorded among the Southeastern states of Nigeria. There was a paucity of published articles from the Northeastern states of Nigeria. There was a significant heterogeneity between studies (I2 > 90%, p < 0.001), but meta-regression analysis only explained < 10% of it. This study has shown that the prevalence of TB/HIV coinfection remains significantly high in Nigeria. Constant surveillance should be rigorously implemented with special attention given to the Northeast due to the ongoing crises that are compounding the problem.

中文翻译：

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尼日利亚结核病和艾滋病毒的双重感染：系统评价和荟萃分析。

结核病 (TB) 和艾滋病毒/艾滋病是全球主要的公共卫生问题。由于结核病和艾滋病毒/艾滋病的流行率很高，这些疾病的负担在尼日利亚尤为严重。这项荟萃分析首次探讨了尼日利亚区域层面的结核病/艾滋病毒双重感染流行情况。使用精心构建的关键词组合，从 PUBMED、ScienceDirect、African Journals Online 和 Cochrane 图书馆数据库中获取了总共 58 篇相关出版物，其中包括 80 项研究 (n = 44,508)。本荟萃分析遵循 PRISMA 指南。两名独立评审员进行了出版物筛选、数据提取和方法学质量评估，第三名评审员担任仲裁员。使用随机效应模型计算汇总估计值。使用 Cochran 的 Q 和 I 2 统计量评估异质性。进行单变量和多变量荟萃回归来预测研究间异质性的来源。总体而言，结核病/艾滋病毒合并感染的汇总患病率为 25.8%。尼日利亚中北部各州的合并感染率最高，为 34.3%，而尼日利亚东南部各州的合并感染率最低，为 19.3%。尼日利亚东北部各州发表的文章很少。研究之间存在显着的异质性（I2 > 90%，p < 0.001），但荟萃回归分析仅解释了< 10%。这项研究表明，尼日利亚结核病/艾滋病毒双重感染的患病率仍然很高。由于持续不断的危机使问题变得更加复杂，因此应严格实施持续监控，并特别关注东北地区。