Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP). Acute senescence induction protects against cancer and limits fibrosis, but lingering senescent cells drive age-related disorders. Thus, targeting senescent cells to delay aging and limit dysfunction, known as “senotherapy,” is gaining momentum. While drugs that selectively kill senescent cells, termed “senolytics” are a major focus, SASP-centered approaches are emerging as alternatives to target senescence-associated diseases. Here, we summarize the regulation and functions of the SASP and highlight the therapeutic potential of SASP modulation as complimentary or an alternative to current senolytic approaches.

中文翻译：

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衰老和SASP：许多治疗途径

细胞衰老是一种应激反应，引起永久性细胞周期停滞并引发深刻的表型改变，例如生物活性分泌物组的产生，称为衰老相关分泌表型（SASP）。急性衰老诱导可预防癌症并限制纤维化，但是挥之不去的衰老细胞会引发与年龄有关的疾病。因此，靶向衰老细胞以延缓衰老和限制功能障碍（称为“ senotherapy”）正在获得发展势头。虽然选择性杀灭衰老细胞的药物（称为“衰老药”）是主要焦点，但以SASP为中心的方法正在成为靶向衰老相关疾病的替代方法。这里，