Highly Branched Gradient Glycopolymer: Enzyme-Assisted Synthesis and Enhanced Bacteria-Binding Ability,Biomacromolecules

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Highly Branched Gradient Glycopolymer: Enzyme-Assisted Synthesis and Enhanced Bacteria-Binding Ability
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-12-01 , DOI: 10.1021/acs.biomac.0c01311
Lifang Zheng ₁ , Yan Luo ₂ , Kui Chen ₁ , Zexin Zhang ₂ , Gaojian Chen _{1,

2}

Affiliation

A one-pot strategy was applied to synchronize enzymatic monomer transformation with reversible addition fragmentation chain transfer (RAFT) polymerization for the synthesis of glycopolymers with highly branched gradient architectures. Also, the linear analogues, block glycopolymers, and gradient glycopolymers were also synthesized for comparison. The binding ability of glycopolymers toward bacteria was then studied by optical density (OD) test, confocal laser scanning microscopy (CLSM), and quartz crystal microbalance with dissipation (QCM-D). The results show that the highly branched gradient glycopolymers have the most remarkable bacteria-binding ability compared with the two linear analogues, gradient glycopolymers, and block glycopolymers. The highly branched glycopolymers were further used as inhibitors in the anti-infection test, demonstrating a significant inhibitory effect on preventing bacteria from infecting the cells.

中文翻译：

高度分支的梯度糖聚合物：酶辅助合成和增强的细菌结合能力

应用一锅策略将酶促单体转化与可逆加成断裂链转移（RAFT）聚合同步，以合成具有高度分支梯度结构的糖聚合物。另外，还合成了线性类似物，嵌段糖聚合物和梯度糖聚合物用于比较。然后通过光密度（OD）测试，共聚焦激光扫描显微镜（CLSM）和带耗散的石英晶体微天平（QCM-D）研究了糖聚合物对细菌的结合能力。结果表明，与两种线性类似物梯度糖聚合物和嵌段糖聚合物相比，高度分支的梯度糖聚合物具有最显着的细菌结合能力。高度支化的糖聚合物在抗感染试验中进一步用作抑制剂，

更新日期：2020-12-14

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